自组装短肽水凝胶:止血效应与机制研究进展

Self-assembling peptide hydrogel: hemostatic effect and mechanism

背景:自组装短肽水凝胶作为一种新型的生物材料,被广泛应用于组织工程、药物释放、止血和抗菌剂等方面。目的:总结近年来自组装短肽水凝胶材料在不同出血模型中的止血效应和机制研究进展。方法:以"自组装短肽,水凝胶,止血,外伤;self-assembling peptide,hydrogel,hemostas is,trauma"为检索词,检索PubMed、CNKI、万方数据库2000至2018年发表的相关文献。结果与结论:自组装短肽材料具有可编程、黏弹性好、生物相容性高和低免疫原性等特性;自?组装短肽?在生理条件下可形成纳米纤维水凝胶,表现出良好的生物相容性,在不同外科手术伤口中,水凝胶可形成物理屏障,发挥止血效果,而不与凝血级联相互作用或受凝血级联影响,快速有效地控制出血而不伤害周围组织或细胞。合理利用短肽的抗菌和药物缓释特性,在保证快速止血效应的同时,改善伤口微环境,联合生物活性分子共同促进伤口愈合,是现阶段自组装短肽材料的重点研究方向之一。

BACKGROUND:As a new type of biomaterial,self-assembling peptide hydrogel is widely used in tissue engineering,drug release,hemostasis and antibacterial agents.OBJECTIVE:To summarize the hemostatic effect and mechanism of self-assembling peptide hydrogel materials in different bleeding models.METHODS:Using“self-assembling peptide,hydrogel,hemostasis,trauma”as the key words in Chinese and English,respectively,we retrieved the related literatures published from 2000 to 2018 in PubMed,CNKI,WanFang databases.RESULTS AND CONCLUSION:Self-assembling peptide materials are characterized as programmability,good viscoelasticity,high biocompatibility and low immunogenicity.The short peptides can self-assemble into nanofiber hydrogels and exhibit good biocompatibility.In different surgical wounds,hydrogels can form physical barriers to exert hemostasis without interacting with the clotting cascade or being coagulated,which can quickly and effectively control bleeding without harm to surrounding tissues or cells.Reasonable use of short peptides that have antibacterial and drug sustained-release properties can ensure rapid hemostatic effect,and meanwhile improve wound microenvironment.Self-assembling peptide hydrogel combined with bioactive molecules to promote wound healing is one of the key research directions of self-assembling short peptide materials at this stage.