期刊文献+

胃癌干细胞在胃癌靶向治疗中的研究进展 被引量:2

下载PDF
导出
摘要 越来越多的证据表明,胃癌干细胞参与胃癌的侵袭、转移和治疗耐药性的进程。随着识别、分离和验证干细胞技术的不断完善,已经初步阐明了胃癌干细胞特异性标记物和相关信号通路,这可能为基于根除胃癌干细胞为目标的胃癌治疗提供了新思路。本文就胃癌干细胞的来源及分离、鉴定特性,针对胃癌干细胞表面标记、自我更新相关信号通路及端粒酶活性的靶向治疗作一综述。
出处 《癌变.畸变.突变》 CAS CSCD 2018年第6期490-493,共4页 Carcinogenesis,Teratogenesis & Mutagenesis
基金 国家自然科学基金项目(81660468)
  • 相关文献

参考文献1

二级参考文献29

  • 1Correa P. Piazuelo MB, Wiluon KT Pathology of gastric in, testinal mctaplasia: clinical implications. Am J Gastroenterol 2010; 105:493-498.
  • 2Khan FA, Shukla AN. Pathogenesis and treatment of gastric carcinoma: "an up-date with brief review". J Cancer Res Ther 2006; 2:196-199.
  • 3Anderson WF, Camargo MC, Fraumeni JF, et al. Age-specific trends in incidence of noncardia gastric cancer in US adults. Jama-JAm MedAssoc 2010; 303:1723-1728.
  • 4Chen CY, Hsu JS, Wu DC, et al. Gastric cancer: preoperative local staging with 3D multi-detector row CT - correlation with surgical and histopathologic results. Radiology 2007; 242:472-482.
  • 5House MG, Brennan MF. Neoadjuvant therapy for gastric cancer. Adv Surg 2008; 42:151-168.
  • 6Reya T, Morrison S J, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414:105-111.
  • 7Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietie cell. Nat Med 1997; 3:730-737.
  • 8Polyak K, Hahn WC. Roots and stems: stem cells in cancer. Nat Med 2006; 12:296-300.
  • 9Eaves CJ. Cancer stem cells: Here, there, everywhere? Nature 2008; 456:581-582.
  • 10AI-Hajj M, Wicha MS, Benito-Hemandez A, Morrison S J, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100:3983-3988.

共引文献50

同被引文献21

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部