骨代谢主要信号通路及信号分子的研究进展

Research progress of major signal pathways and signaling molecules in bone metabolism

骨质疏松是以骨量降低和骨脆性增加为特征的骨病。成骨细胞的成骨分化及胞外基质的矿化是骨量维持的重要过程,这一过程受多条胞内信号传导通路的调控。本文综述与骨代谢相关的主要信号通路,包括Wnt通路、BMP、RANKl以及NOTCH通路,以及参与这些通路信号传导的关键分子,通过人为干预这些分子的表达或通路的激活,使骨代谢向需要的方向倾斜,为骨质疏松的治疗提供新的潜在靶点。

Osteoporosis is a disease characterized by decreased bone mass and increased bone fragility.The osteogenic differentiation of osteoblasts and the mineralization of extracellular matrix are important processes of bone mass maintenance,which is regulated by multiple intracellular signal transduction pathways.This article reviews the major pathways related to bone metabolism,including Wnt,BMP,RANKL and NOTCH signaling pathways,and the key molecules involved in these pathways.By intervening the activation of these pathways,bone metabolism can be regulated.This may explore a potential target for the treatment of osteoporosis.