老年慢性支气管哮喘患者血清IL-12、IL-18的表达及意义分析

Expression and significance of serum IL-12 and IL-18 in elderly patients with chronic bronchial asthma

目的:对老年慢性支气管哮喘病患血清白细胞介素(IL-12)、白细胞介素(IL-18)的表达及意义进行研究分析。方法:选择我院2016年8月至2017年7月接诊的100例老年慢性支气管哮喘病患为研究组,并随机抽取同期行体检的健康成人100例为对照组,分别对两组人员血清中的IL-12、IL-18的表达水平进行检测比较。结果:研究组病患血清IL-12表达水平显著低于对照组,IL-18表达水平显著高于对照组,差异均具统计学意义(P <0. 05);另研究组病患IL-12和IL-18的表达水平同病变阶段相关,并且两者呈负相关性。结论:在老年慢性支气管哮喘病患发病中,IL-12和IL-18均参与了其病变的形成与发展,并在不同病变阶段其表达水平明显不同,两者存在负相关性。

Objective:To study and analyze the expression and significance of serum interleukin-12(IL-12)and interleukin-18(IL-18)in elderly patients with chronic bronchial asthma.Methods:100 patients with chronic bronchial asthma from August 2016 to July 2017 were selected as the research group.In addition,100 healthy adults were selected as the control group.The expression levels of IL-12 and IL-18 in the serum of the two groups were compared.Results:Serum IL-12 expression level in the study group was significantly lower than that in the control group,and the expression level of IL-18 in the study group was significantly higher than that of the control group(P<0.05).The expression levels of IL-12 and IL-18 were correlated with the lesion stage,and the two were negatively correlated.Conclusion:In elderly patients with chronic bronchial asthma,IL-12 and IL-18 are both involved in the formation and development of their lesions.The expression levels of IL-12 and IL-18 are significantly different in different stages,and there is a negative correlation between the two.