重度睡眠呼吸暂停患者同型半胱氨酸相关性研究

Study on the correlation of homocysteine with patients with severe sleep apnea

目的:分析重度睡眠呼吸暂停患者同型半胱氨酸的相关性。方法:选择医院2015年12月至2017年12月收治的50例重度睡眠呼吸暂停综合症患者作为观察组,并选择同期收治的50例健康体检者作为对照组;对研究对象的空腹同型半胱氨酸浓度、空腹血糖、肌酐、尿素氮进行检测,观察比较检测结果。观察组患者给予为期1周的夜间持续正压通气治疗,再次对空腹同型半胱氨酸浓度进行检测,观察比较治疗前后的同型半胱氨酸浓度。结果:观察组的同型半胱氨酸浓度显著高于对照组,差异有统计学意义(P <0. 05);对照组的肌酐、空腹血糖以及尿素氮浓度较观察组差异无统计学意义(P> 0. 05)。观察组患者治疗后的同型半胱氨酸浓度低于治疗前(P <0. 05)。结论:同健康人群相比较,重度睡眠呼吸暂停综合症患者的同型半胱氨酸浓度上升,通过持续正压通气治疗能让重度睡眠呼吸暂停综合症患者的同型半胱氨酸浓度降低。

Objective:To analyze the relationship between severe sleep apnea and homocysteine.Methods:50 patients with severe sleep apnea syndrome admitted in our hospital from December 2015 to December 2017 were selected as the experimental group,and 50 cases of healthy examinees were selected as the control group.The fasting homocysteine concentration,fasting blood glucose,creatinine,urea nitrogen of the subjects were detected and compared.The patients in the experimental group received continuous positive pressure ventilation overnight for 1 week.After treatment,the fasting concentration of homocysteine was measured again,and the levels before and after treatment were compared.Results:The homocysteine concentration in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistical difference in the creatinine,fasting blood glucose and urea nitrogen concentration between the control group and the experimental group(P>0.05).The homocysteine concentration in the experimental group after treatment was significantly lower than that before treatment,the difference was statistically significant(P<0.05).Conclusions:Compared to healthy subjects,the patients with severe sleep apnea syndrome have significantly higher homocysteine levels.Consecutive positive pressure ventilation can significantly reduce homocysteine concentrations in patients with severe sleep apnea syndrome.