超声引导下聚桂醇辅助射频消融术对子宫肌瘤患者子宫肌瘤体积、内分泌功能的影响

The influences of ultrasound guided radiofrequency ablation assisted by polyol on fibroid volume and endocrine function among patients with uterine fibroid

目的探讨超声引导下聚桂醇辅助射频消融术对子宫肌瘤患者子宫肌瘤体积、内分泌功能的影响。方法选取子宫肌瘤患者92例作为研究对象,随机将其划分成两组,对照组46例采取超声引导射频消融术治疗,观察组46例实施超声引导下聚桂醇辅助射频消融术治疗,对比两组患者临床疗效、子宫及肌瘤体积、内分泌状况、子宫肌瘤症状严重程度和生活质量。结果观察组总有效率为95.65%,对照组为80.43%,差异有统计学意义(P<0.05)。两组治疗前子宫及肌瘤体积比较差异均无统计学意义(均P> 0.05);治疗后子宫及肌瘤体积均小于治疗前(均P<0.05),且观察组均小于对照组(P<0.05)。两组治疗前雌二醇(E2)、促黄体素(LH)、促卵泡生成激素(FSH)水平比较差异均无统计学意义(均P> 0.05);治疗后两组E2、LH、FSH水平均低于治疗前(均P<0.05),但组间比较差异均无统计学意义(均P> 0.05)。两组治疗前SSS、HR-QOL评分比较差异均无统计学意义(均P> 0.05);治疗后,两组SSS评分均低于治疗前(均P<0.05),HR-QOL均高于治疗前(均且组间差异均有统计学意义(均P<0.05)。两组并发症发生率比较差异无统计学意义(P> 0.05)。结论对子宫肌瘤患者实施超声引导下聚桂醇辅助射频消融术治疗可明显缩小子宫肌瘤体积,有效改善内分泌功能及生活质量,效果显著且具有较高的安全性。

Objective To investigate the influences of ultrasound guided radiofrequency ablation assisted by polyol on fibroid volume and endocrine function of patients with uterine fibroid. Methods Ninety-two patients with uterine fibroid admitted were randomly divided into two groups.Forty-six cases in the control group were treated with ultrasound guidedradiofrequency ablation, and 46 cases in the observation group were treated with ultrasound guided radiofrequency ablation assisted by polyol.The clinical efficacy, uterus and fibroid volumes, endocrine status, uterine fibroid symptom severity and quality of life were compared between the two groups. Results The total effective rate of the observation group was 95.65%, which was significantly higher than 80.43% of the control group( < 0.05).After three months of treatment, the volumes of uterus and fibroid were significantly smaller than those before treatment( all < 0.05), and thevolumes of observation group were smaller than those of the control group( all <0.05). The levels of estradiol(E2), luteinizing hormone(LH) and follicle stimulating hormone(FSH) of both groups after three months of treatment were lower than those of before treatment(all < 0.05); however, there was no significant differencebetween the observation group and the control group( > 0.05). The symptom severity score(SSS)of the two groups after three months of treatment was lower than than those of before treatment, while the quality of life score(HR-QOL) was higher than that of before treatment( < 0.05), and there was a significant difference between the two groups( < 0.05).There was no significant difference in the incidence rate of complications between the two groups( > 0.05). Conclusions Ultrasound guided radiofrequency ablation assisted by polyol for fibroid patients can significantly reduce the volumes of uterus and fibroid, effectively improve the endocrine function and quality of life, and it has high safety.