连续性血液净化对重症急性胰腺炎患者肠道屏障功能的影响观察

Observation on Influence of Continuous Blood Purification on Intestinal Barrier Function in Patients with Severe Acute Pancreatitis

目的探讨连续性血液净化对重症急性胰腺炎患者肠道屏障功能的影响。方法选取我院2015年1月至2017年12月收治的80例重症急性胰腺炎患者,随机分为对照组(n=40,予以常规治疗)与观察组(n=40,予以常规治疗+连续性血液净化),观察两组患者的临床疗效。结果观察组的腹痛缓解时间、住院时间及血淀粉酶恢复正常时间显著短于对照组(P <0.05)。治疗后,两组APACHEⅡ评分及血清DAO、 D-乳酸、血浆内毒素水平显著降低,且观察组的APACHEⅡ评分及血清DAO、 D-乳酸、血浆内毒素水平明显低于对照组(P均<0.05)。观察组的病死率及并发症发生率均显著低于对照组(P <0.05)。结论连续性血液净化能够显著改善重症急性胰腺炎患者的肠道屏障功能,疗效确切,能够显著降低并发症发生率及病死率,具有临床推广价值。

Objective To explore the influence of continuous blood purification on intestinal barrier function in patients with severe acute pancreatitis.Methods 80 cases of patients with severe acute pancreatitis admitted to our hospital from January 2015 to December 2017 were selected and randomly divided into control group(n=40,routine treatment)and observation group(n=40,routine treatment+continuous blood purification).The clinical curative effects of two groups were observed.Results The abdominal pain relief time,hospitalization time and the recovery time of blood amylase were significantly shorter than those of the control group(P<0.05).After treatment,the APACHEⅡscores and serum DAO,D-lactic acid and plasma endotoxin levels of two groups decreased significantly,and the APACHEⅡscore and serum DAO,D-lactic acid and plasma endotoxin levels of the observation group were significantly lower than those of the control group(all P<0.05).The mortality and incidence of complications of the observation group were significantly lower than those of the control group(P<0.05).Conclusions Continuous blood purification can significantly improve the intestinal barrier function of patients with severe acute pancreatitis,with definite curative effect,and can significantly reduce the incidence of complications and mortality,which has clinical promotion value.