妊娠期糖尿病对体外受精-胚胎移植双胎妊娠结局的影响

Influence of Gestational Diabetes Mellitus on Outcomes of Twin Pregnancy of in Vitro Fertilization-Embryo Transfer

目的探讨妊娠期糖尿病(GDM)对体外受精-胚胎移植(IVF-ET)双胎妊娠结局的影响。方法回顾性分析我院2017年1月至2017年12月收治的100例IVF-ET术后双胎妊娠合并GDM孕妇与43例IVF-ET术后正常双胎妊娠孕妇的临床资料,根据是否对GDM采取合理的措施,将IVF-ET双胎妊娠合并GDM孕妇分为GDM观察组(32例)和GDM治疗组(68例), 43例IVF-ET正常双胎妊娠孕妇作为对照组,比较各组的并发症情况以及围产儿疾病情况。结果 GDM观察组的剖宫产、产后出血、胎膜早破、产后感染的发生率与围产儿畸形、窒息、高胆红素血症发生率均显著高于对照组(P <0.05)。GDM治疗组的剖宫产、产后出血、胎膜早破、产后感染的发生率与围产儿畸形、窒息、高胆红素血症发生率均显著低于GDM观察组(P<0.05)。结论 GDM严重影响IVF-ET双胎妊娠孕妇与围产儿的预后,若及时发现并正确处理,可显著改善母婴结局。

Objective To explore the influence of gestational diabetes mellitus(GDM)on outcomes of twin pregnancy of in vitro fertilization-embryo transfer(IVF-ET).Methods The clinical data of 100 twin pregnant women with GDM after IVF-ET and 43 cases of normal twin pregnant women after IVF-ET were retrospectively analyzed in our hospital from January 2017 to December 2017.According to whether the reasonable measures were taken for GDM,the IVF-ET twin pregnant women with GDM were divided into GDM observation group(n=32)and GDM treatment group(n=68),and the 43 cases of IVF-ET normal twin pregnant women were selected as control group.The complications and perinatal diseases were compared among the groups.Results The incidences of cesarean section,postpartum hemorrhage,premature rupture of membranes and postpartum infection,and perinatal malformation,asphyxia and hyperbilirubinemia of the GDM observation group were significantly higher than those of the control group(P<0.05),and the above-mentioned incidences of the GDM treatment group were significantly lower than those of the GDM observation group(P<0.05).Conclusions GDM severely affects the prognosis of IVF-ET twin pregnant women and perinatal infants.Timely discovery and correct treatment can significantly improve the maternal-fetal outcomes.