标准外伤大骨瓣开颅术联合局部亚低温治疗重型颅脑损伤的临床研究

Clinical Study of Standard Large Trauma Craniotomy Combined with Mild Hypothermia in the Treatment of Severe Craniocerebral Injury

目的探讨标准外伤大骨瓣开颅术联合局部亚低温治疗重型颅脑损伤患者的临床疗效。方法选取我院2015年5月至2018年5月收治的重型颅脑损伤患者102例,随机分为对照组(予以标准外伤大骨瓣开颅术治疗)与观察组(予以局部亚低温联合标准外伤大骨瓣开颅术治疗)各51例。观察两组患者的临床预后及相关指标。结果治疗后3个月,两组的DRS评分均降低,而观察组的DRS评分低于对照组(P均<0.05)。治疗后14 d时,两组的GCS评分均提高,而观察组的GCS评分高于对照组(P均<0.05)。观察组的预后良好率高于对照组(P <0.05)。观察组的并发症发生率低于对照组(P <0.05)。结论局部亚低温疗法联合标准外伤大骨瓣开颅术治疗重型颅脑损伤患者,可明显改善患者预后及神经功能,减少并发症,具有临床推广价值。

Objective To explore the clinical curative effect of standard large trauma craniotomy combined with partial mild hypothermia in the treatment of patients with severe craniocerebral injury.Methods 102 cases of patients with severe craniocerebral injury admitted to our hospital from May 2015 to May 2018 were selected and randomly divided into control group(standard large trauma craniotomy)and observation group(partial mild hypothermia combined with standard large trauma craniotomy).The clinical outcomes and related indicators of two groups were observed.Results 3 months after treatment,the DRS scores of both groups decreased,and the DRS score of the observation group was lower than that of the control group(P<0.05).14 d after treatment,the GCS scores of both groups improved,and the GCS score of the observation group was higher than that of the control group(P<0.05).The good prognosis rate of the observation group was higher than that of the control group(P<0.05).The incidence of complications of the observation group was lower than that of the control group(P<0.05).Conclusions Standard large trauma craniotomy combined with partial mild hypothermia in the treatment of patients with severe craniocerebral injury can significantly improve patients'prognosis and neural function,reduce the complications with clinical promotion value.