潜在的器官供体来源:“次优”遗体器官研究现状

Potential Source of Donors' Organ:the research progress of suboptimal organs from deceased-donor

器官移植是很多终末期患者(如晚期癌症、肾衰竭等)的主要治疗方法,但是捐献器官在全球范围内都是供不应求。为了解决这个问题,各国政府长期致力于提高活体器官以及遗体器官的捐献率,但却忽视了一个很重要的潜在器官来源,即那些因为捐献者年龄太大、病毒感染(如丙型肝炎)、心死亡等各种原因被放弃的"次优(suboptimal)"遗体器官。受益于医疗技术的迅速发展,以前被认为不适合进行移植的次优遗体器官现在变成了潜在的供体。因此,本文通过文献分析,对国外关于"次优"遗体器官的研究进展进行详细的介绍,以期为致力于器官移植事业的中国临床工作者提供一些研究方向。

Organ transplantation is the primary treatment for many patients with end-stage diseases(i.e,advanced cancer,uremia,etc),but the supply of organs is far from enough across the world.Different approaches have been adapted to increase rates of donation both from living and deceased donors but a substantial number of deceased-donor organs are discarded in consideration of older age,hepatitis C virus infection and cardiac arrest,which is a potential source for organ transplantation.However,new medical technics have been developed to improve the transplantation of suboptimal organs that were previously considered unusable.Thus,this study is designed to report the updates of research about suboptimal organ,providing the clinicians some suggestions for further organ transplantation researches in China.