含铋四联疗法联合双歧杆菌四联活菌片治疗Hp阳性消化性溃疡的疗效及对Hp根除率、不良反应的影响

Efficacy of of sputum-containing quadruple therapy combined with Bifidobacterium quadruple live bacteria tablets on Hp-positive peptic ulcer and its effect on Hp eradication rate and adverse reactions

目的研究含铋四联疗法联合双歧杆菌四联活菌片治疗幽门螺杆菌(Hp)阳性消化性溃疡(PU)的疗效及对患者Hp根除率、不良反应的影响。方法 100例Hp阳性消化性溃疡患者,按照随机数字表法分为对照组及观察组,各50例。对照组采用含铋四联疗法治疗,观察组在对照组基础上服用双歧杆菌四联活菌片治疗,两组均治疗2个月。比较两组患者的临床疗效、Hp根除情况及不良反应发生情况。结果观察组总有效率为96.00%,高于对照组的74.00%,差异有统计学意义(P<0.05)。观察组不良反应发生率为14.00%,低于对照组的32.00%,差异具有统计学意义(P<0.05)。观察组Hp根除率为92.00%,高于对照组的70.00%,差异有统计学意义(P<0.05)。结论含铋四联疗法联合双歧杆菌四联活菌片治疗Hp阳性消化性溃疡疗效显著。

Objective To study the efficacy of sputum-containing quadruple therapy combined with Bifidobacterium quadruple live bacteria tablets on Helicobacter pylori(Hp)-positive peptic ulcer(PU)and its effect on Hp eradication rate and adverse reactions.Methods A total of 100 Hp-positive peptic ulcer patients were divided by random number table into control group and observation group,with 50 cases in each group.The control group received sputum-containing quadruple therapy,and the observation group received Bifidobacterium quadruple live bacteria tablets on the basis of the control group.Both groups were treated for 2 months.The efficacy,Hp eradication rate and incidence of adverse reactions were compared between the two groups.Results The observation group had higher total effective rate as 96.00%than 74.00%in the control group,and the difference was statistically significant(P<0.05).The observation group had lower incidence of adverse reactions as 14.00%than 32.00%in the control group,and the difference was statistically significant(P<0.05).The observation group had higher Hp eradication rate as 92.00%than 70.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of sputum-containing quadruple therapy and Bifidobacterium quadruple live bacteria tablets shows excellent efficacy in treating Hp-positive peptic ulcer.