生物医用硅橡胶表面抗菌性能改造研究进展

Research progress of surface modification of antibacterial performance of biomedical silicone rubber

硅橡胶材料由于其优越的力学性能及良好的生物相容性,广泛应用于生物医学领域。但使用过程中易引发细菌感染,严重阻碍其临床应用,因此硅橡胶材料的抗菌性能改造成为国内外专家的研究热点。本文综述了近些年关于硅橡胶表面抗菌性能改造的研究成果,介绍了硅橡胶表面的亲水性改造以及不同种类的杀菌剂涂层对材料表面的改性可以有效地提升其抗菌性能。最后对硅橡胶表面抗菌性能改造研究进行展望,指出将亲水化合物与杀菌剂相结合制备出具有抗粘附及杀菌效果的双功能抗菌涂层对硅橡胶表面抗菌性能改造将成为下一步研究重点,同时采用天然可再生资源为原料开发抗菌涂层也将成为重要的研究方向之一。

Silicone rubber materials are widely used in the biomedical field because of their superior mechanical properties and good biocompatibility.However,bacterial infection often occurs during their use,which seriously hinders their clinical application.Therefore,the improvement of the antibacterial properties of silicone rubber materials has become a research hotspot.This review summarizes and analyzes the antibacterial properties of the surface of silicone rubber.The hydrophilic transformation and the modification of the surface with different types of bactericide can effectively improve the antibacterial performance.Finally,the antibacterial properties of silicone rubber surface modification research prospects are expected.we point out that the combination of hydrophilic compounds and bactericide to prepare bifunctional antibacterial coating will become the focus of future research.Besides,the use of natural raw materials in the development of antimicrobial coatings will also become an important research direction.