YAP、E-cadherin和Vimentin在口腔鳞癌中的表达及临床意义

Expression and clinical significance of YAP,E-cadherin and Vimentin in oral squamous cell carcinoma

采用免疫组化法检测54例口腔鳞癌及其癌旁组织中Yes相关蛋白(YAP)与上皮间质转化(EMT)相关蛋白Ecadherin、Vimentin的表达情况,探讨其临床意义。YAP、Vimentin在口腔鳞癌中的阳性表达高于癌旁组织(P <0. 01),Ecadherin的阳性表达低于癌旁组织(P <0. 01); YAP的阳性率与病理分级、淋巴结转移相关(P <0. 05); E-cadherin、Vimentin的阳性率与临床分期、病理分级、淋巴结转移相关(P <0. 05); YAP与E-cadherin的表达呈负相关性(r=-0. 424,P<0. 01),与Vimentin的表达呈正相关性(r=0. 519,P <0. 01)。YAP可能通过调控EMT过程促进口腔鳞癌的侵袭转移。

The immunohistochemical method was used to detect the expression of Yes-associated protein(YAP),epithelial mesenchymal transition(EMT)associated proteins E-cadherin and Vimentin in 54 cases of oral squamous cell carcinoma and adjacent tissues,then the clinical significance was discussed.The positive expression of YAP and Vimentin in oral squamous cell carcinoma was higher than that of adjacent tissues(P<0.01),the positive expression of E-cadherin was lower than that of adjacent tissues(P<0.01).The positive rate of YAP was correlated with pathological grades and lymph node metastasis(P<0.05).The positive rate of E-cadherin and Vimentin was correlated with clinical stags,pathological grades and lymph node metastasis(P<0.05).The expression of YAP was negatively correlated with E-cadherin(r=-0.424,P<0.01)but positively correlated with Vimentin in oral squamous cell carcinoma(r=0.519,P<0.01).YAP may promote the invasion and metastasis of oral squamous cell carcinoma by regulating epithelial mesenchymal transition.