多囊卵巢综合征患者妊娠早期血清抵抗素水平对妊娠并发症及不良妊娠结局的影响

Effects of serum resistin on pregnancy complications and adverse pregnancy outcomes in patients with PCOS

目的观察多囊卵巢综合征(PCOS)患者妊娠早期血清抵抗素水平对妊娠并发症及不良妊娠结局的影响。方法采用前瞻性研究方法,选取2016年7月至2018年2月西北妇女儿童医院妇产科收治的92例PCOS早期妊娠妇女作为观察组,同时选取同期92例健康妊娠妇女作为对照组,检测两组受试者的血清抵抗素水平,分析其对妊娠并发症及不良妊娠结局的影响。结果对照组受试者血清抵抗素水平为(4. 22±0. 54)μg/L,观察组患者为(6. 83±1. 24)μg/L,观察组患者血清抵抗素水平明显高于对照组(t=4. 265,P <0. 05);随着血清抵抗素水平的升高,妊娠并发症发生率、不良妊娠发生率也随之增高,组间比较差异具有统计学意义(P <0. 05)。结论 PCOS患者妊娠早期血清抵抗素水平明显升高,且其妊娠并发症发生率及不良妊娠结局总发生率随血清抵抗素水平的升高而升高。

Objective To observe the effect of serum resistin in early pregnancy on pregnancy complications and adverse pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods A prospective study was conducted including 92 PCOS early-pregnancy women admitted to the Department of Obstetrics and Gynecology,Northwest Women and Children's Hospital from July 2016 to February 2018.92 healthy pregnant women were selected as the control group.Serum resistin levels were analyzed for effects on pregnancy complications and adverse pregnancy outcomes.Results The serum resistin level in the control group was(4.22±0.54)μg/L,and that in the observation group was(6.83±1.24)μg/L.The serum resistin level in the observation group was significantly higher than that in the control group(t=4.265,P<0.05);With the increase of serum resistin level,the incidence of pregnancy complications and the incidence of adverse pregnancy also increased,the difference between the groups was statistically significant(P<0.05).Conclusion The serum resistin level of patients with PCOS pregnancy was significantly increased,and the incidence of pregnancy complications and adverse pregnancy outcomes increased with the increase of serum resistin level.