血浆suPAR与IgA肾病患者局部节段性肾小球硬化的相关性分析

Correlation between plasma suPAR and focal segmental glomerulosclerosis in patients with IgA nephropathy

目的分析血浆可溶性尿激酶型纤溶酶原激活物受体(suPAR)与免疫球蛋白A(IgA)肾病患者局部节段性肾小球硬化的相关性。方法回顾性分析75例IgA肾病患者的临床资料,对其血浆suPAR浓度进行检测。采用Pearson相关性分析血浆suPAR浓度与IgA肾病患者各项临床指标的相关性,并用单因素分析和多元线性回归分析血浆suPAR浓度与患者伴发局部节段性肾小球硬化的相关性。结果 IgA肾病患者血浆suPAR浓度为897. 98～3 989. 68pg/ml,平均为(2 109. 46±325. 35) pg/ml。经Pearson相关性分析结果显示,患者血浆suPAR浓度与年龄、超敏C反应蛋白(hs-CRP)、血尿素氮(BUN)及24小时蛋白尿均存在正相关关系(P <0. 05),与血红蛋白(HGB)、红细胞计数(RBC)、血肌酐(SCr)及肾小球滤过率估计值(eGFR)浓度均存在负相关关系(P <0. 05),而与血小板计数(PLT)、白细胞计数(WBC)、尿酸(UA)水平均无显著性关系(P> 0. 05)。75例IgA肾病患者中,33例患者伴有局部节段性肾小球硬化。经单因素分析结果显示,伴有局部节段性肾小球硬化的IgA肾病患者血浆suPAR浓度较无局部节段性肾小球硬化者明显升高(P <0. 01);经多元线性回归分析结果显示,性别、年龄、SCr、伴局部节段性肾小球硬化与血浆suPAR浓度均密切相关(P <0. 01)。结论 IgA肾病患者血浆suPAR浓度与患者年龄、肾功能均存在显著关系,故此可作为评估IgA肾病患者局部节段性肾小球硬化的潜在预测因子。

Objective To analyze the correlation between plasma soluble urokinase-type plasminogen activator receptor(suPAR)and focal segmental glomerulosclerosis in patients with immunoglobulin A(IgA)nephropathy.Methods The clinical data of 75 patients with IgA nephropathy were analyzed retrospectively.The plasma suPAR concentration was measured.The correlation between the plasma suPAR concentration and the clinical parameters of IgA nephropathy was analyzed by Pearson correlation.The correlation between the plasma suPAR concentration and the focal segment glomerulosclerosis was analyzed by univariate analysis and multiple linear regression analysis.Results The plasma concentration of suPAR in patients with IgA nephropathy ranged from 897.98 to 3 989.68 pg/ml,with an average of(2 109.46±325.35)pg/ml.Pearson correlation analysis showed that the plasma suPAR concentration was positively correlated with ages,High sensitivity C reactive protein(hs-CRP),blood urea nitrogen(BUN)and 24 hour proteinuria(P<0.05),and was negative correlations with hemoglobin(HGB),red blood cell count(RBC),serum creatinine(SCr)and estimated glomerular filtration rate(eGFR)concentrations(P<0.05),while showed no significant correlation between platelet count(PLT),white blood cell count(WBC)and uric acid(UA)levels(P>0.05).Of the 75 patients with IgA nephropathy,33 showed focal segmental glomerulosclerosis.The results of univariate analysis showed that the plasma suPAR concentration in patients with IgA nephropathy complicated with focal segmental glomerulosclerosis was significantly higher than that in IgA nephropathy patients without focal segmental glomerulosclerosis(P<0.01);multivariate linear regression analysis showed that sex,age,SCr,with focal segmental glomerulosclerosis were closely related to plasma suPAR concentration(P<0.01).Conclusion The plasma suPAR concentration in patients with IgA nephropathy is significantly related to ages and renal function,so it can be used as a potential predictor of focal segmental glomerulosclerosis in patients with IgA nephropathy.