摘要
沙雷氏蛋白酶属于锌金属蛋白酶M10B亚家族,存在于各种致病性革兰氏阴性细菌中。通常具有毒性,是一些疾病的关键致病因子。沙雷氏蛋白酶抑制剂是治疗这些疾病的有效药物,并且可以避免病原菌中的抗生素产生抗性。对沙雷氏蛋白酶和其抑制剂分别进行了综述,并简述了4种沙雷氏蛋白酶与抑制剂复合物相互作用的实例,以期为进一步了解沙雷氏蛋白酶的分泌调控机理和设计新型蛋白酶抑制剂药物提供参考。
Serralysin belongs to the subfamily of zinc metalloprotease M10B and is secreted by a variety of pathogenic gram-negative bacteria.It is a key virulence factor for some diseases.Serralysin inhibitor is an effective drug for treating these diseases and it can prevent antibiotic resistance in pathogenic bacteria.In this paper,serralysin and its inhibitor were reviewed,respectively.Four complexes of them were briefly described,in order to further understand the mechanism of the secretion of serralysin and to provide reference for designing novel inhibitor drugs.
作者
张琳桓
孙谧
王伟
孙晶晶
刘均忠
郝建华
ZHANG Lin-huan;SUN Mi;WANG Wei;SUN Jing-jing;LIU Jun-zhong;HAO Jian-hua(Key Laboratory Sustainable Development of Polar Fishery,Ministry of Agriculture and Rural Affairs,The Yellow Sea FisheriesResearch Institute of Chinese Academy of Fishery Sciences,Qingdao 266071,China;College of Food Science&Technology,Shanghai Ocean University,Shanghai 201306,China;Jiangsu Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resource,Jiangsu 222005,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2018年第11期313-318,共6页
Food and Fermentation Industries
基金
国家实验室-鳌山科技计划(2016ASKJ14)
青岛海洋科学与技术国家实验室海洋生物学与生物技术功能实验室资助(OF2018NO05)。
