黄芪注射液联合亚胺培南西司他丁钠对老年重症感染的疗效分析

Effect of Astragalus injection combined with Imipenem and Cilastatin Sodium on severe infection in the elderly

目的探讨黄芪注射液联合亚胺培南西司他丁钠治疗老年重症感染的疗效。方法按照随机数字表法将纳入的103例老年重症感染患者分为观察组54例和对照组49例。观察组采用黄芪注射液联合亚胺培南西司他丁钠治疗,对照组采用亚胺培南西司他丁钠治疗。两组疗程均为14 d。结果观察组总有效率高于对照组(P<0.05),观察组治疗后CD3^+差值、CD4^+差值、CD4^+/CD8^+差值高于对照组(P<0.05),观察组治疗后CRP、PCT和WBC低于对照组(P <0.05),观察组MODS发生率低于对照组(P <0.05),观察组肠功能恢复时间较对照组短(P <0.05),两组住院病死率比较,差异无统计学意义(P>0.05),观察组不良反应率低于对照组(P<0.05)。结论黄芪注射液联合亚胺培南西司他丁钠治疗老年重症感染患者疗效好,值得临床借鉴。

Objective To investigate the effect of Astragalus injection combined with Imipenem and Cilastatin Sodium on severe infection in the elderly.Methods According to the random table method 103 cases of elderly patients with severe infection selected as the subjects were divided into an observation group(54 cases)and a control group(49 cases).The patients in the observation group were treated with Astragalus injection combined with Imipenem and Cilastatin Sodium,while those in the control group were treated with only Imipenem and Cilastatin Sodium.The course of treatment in both groups was 14 days.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The differences of CD3+T lymphocytes,CD4+T lymphocytes and CD4+/CD8+ratio after treatment in the observation group were bigger than those in the control group(P<0.05).The C-reactive protein,procalcitonin and WBC after treatment in the observation group were lower than those in the control group(P<0.05).The morbidity of MODS in the observation group was significantly lower than that in the control group(P<0.05).The time of intestinal function recovery in the observation group was shorter than that in the control group(P<0.05).There was no significant difference in mortality between the observation group and the control group(P>0.05).The adverse reaction rate of the observation group was lower than that of the control group(P<0.05).Conclusions Astragalus injection combined with Imipenem and Cilastatin Sodium is effective in the treatment of elderly patients with severe infection.