中国东北地区人群饮用绿茶与结直肠癌发病关系的病例对照研究

Green Tea Consumption and Colorectal Cancer Risk:a Case-Control Study in Northeast China

目的探讨饮用绿茶与结直肠癌(CRC)发病的关系。方法采用病例对照研究,收集2009年6月至2011年11月在中国医科大学附属第一医院确诊的新发CRC病例763例,及同期内经年龄、性别及居住地区1∶1匹配的体检人员763例。应用非条件logistic回归计算饮绿茶及相关变量与CRC发病风险的调整OR值及95%CI。结果饮绿茶可降低结直肠癌的发病风险(a OR=0.40,95%CI:0.30～0.52)。饮茶杯数的增加、饮茶年限的延长、干茶叶消费量的增多均与CRC的发病风险降低有关(P <0.05)。饮茶>1杯/d者,CRC发病风险降低65%(a OR=0.35,95%CI:0.23～0.52);饮绿茶年限1～10年与干茶叶消费量500～1 000 g/年者,CRC发病风险分别降低61%(a OR=0.39,95%CI:0.28～0.55)和71%(a OR=0.29,95%CI:0.18～0.49)。发病部位和性别的亚组分析表明,饮绿茶可以降低近端结肠癌、远端结肠癌、直肠癌的发病风险,并降低男性、女性CRC的发病风险。结论饮绿茶是CRC发病的保护因素。

Objective To evaluate the association between green tea consumption and colorectal cancer(CRC)risk in northeast China.Methods This was a matched case-control study involving 763 patients with CRC that had been confirmed by pathological diagnosis,as well as 763 healthy controls that were matched in terms of age frequency,sex and location.All participants were recruited at the China Medical University 1st Hospital between June 2009 and November 2011.Unconditional logistic regression was used to calculate adjusted odds ratios(aORs)and corresponding 95%confidence intervals(CI)to assess the association between green tea consumption and CRC.Results Green tea consumption was associated with a decreased risk of CRC.Moreover,greater daily quantity,longer duration of tea drinking,and greater consumption of dry tea were all related to decreased risk(P<0.05).In participants who drank more than one cup of green tea per day,the risk of CRC was reduced by 65%(aOR=0.35,95%CI:0.23-0.52).In those who drank green tea for 1 to 10 years,the risk of CRC was reduced by 61%(aOR=0.39,95%CI:0.28-0.55),while in those who consumed 500 to 1 000 g of dry tea per year,it was reduced by 71%(aOR=0.29,95%CI:0.18-0.49).When CRC was stratified in terms of subsite,green tea drinking was inversely associated with the risk of proximal colon cancer,distal colon cancer,and rectal cancer.When the participants were stratified by sex,green tea consumption was found to reduce CRC risk in both men and women.Conclusion Green tea drinking is protective against CRC.