有自杀意念双相障碍患者脑灰质体积形态测量分析研究

Changes of gray matter volume in patients with bipolar disorder and suicidal ideation:a voxel based morphometric analysis

目的分析有自杀意念的双相障碍(bipolar disorder, BD)患者、无自杀意念BD患者和健康对照(health control, HC)的脑灰质体积差异,探讨有自杀意念BD特异的脑影像学改变。方法纳入28例有自杀意念BD患者、40例无自杀意念BD患者和46名HC进行磁共振扫描以及基于体素的形态测量分析。结果与HC相比,有无自杀意念BD患者在右侧颞上回和颞中回、左侧尾状核、豆状壳核、枕中回和枕上回灰质体积均有降低,且差异具有统计学意义(P<0.05),而两患者组间未见统计学差异(P>0.05)。在右侧中央后回、顶上回和楔前叶灰质体积,有无自杀意念BD和HC组间差异均存在统计学意义(P<0.05),且有自杀意念BD患者灰质体积低于其他两组(P<0.05)。结论顶叶灰质体积异常可能是有自杀意念BD特异的脑影像学改变。

Objective The study aims to analyze the changes in gray matter among Bipolar Disorder(BD)with suicidal ideation,those without suicidal ideation and health control(HC)and to explore the altered brain imaging changes of BD patients with suicidal ideation.Method The study recruited 28 BD with suicidal ideation,40 BD without suicidal ideation and 46 HCs who undergone the high-resolution structural magnetic resonance imaging.Thus,the data of all participants were analyzed by voxel-based morphometry(VBM).Results Significantly decreased gray matter volume was detected in the right superior temporal gyrus,right middle temporal gyrus,left caudate nucleus,left lenticular putamen,left middle occipital gyrus and left occipital gyrus in patients with BD compared to HCs.However,there was no significant difference in gray matter volume between BD with suicidal ideation and those without suicidal ideation.There were significant differences in gray matter volume in the right postcentral,the right superior parietal gyrus and the right precuneus among BD with and without suicidal ideation and HCs.The gray matter volumes of BD with suicidal ideation were significantly lower than that of the other two groups.Conclusion Gray matter volume abnormalities in parietal lobe play an important role in the brain structural alternation of BD with suicidal ideation.