反流性食管炎和焦虑抑郁的相关性研究

Correlation between reflux esophagitis and anxiety and depression

目的探讨心理因素(焦虑和抑郁)与反流性食管炎(RE)发病的相关性。方法 361例经胃镜检查证实为RE的患者(RE组)和359名健康对照者(对照组)参与此项研究。采用PHQ-9抑郁量表、GAD-7焦虑量表及胃食管反流病问卷(GerdQ)对2组进行评估并比较2组的焦虑、抑郁评分;借助GerdQ评分分析心理因素与患者症状及疾病对日常生活影响的相关性。结果 RE组PHQ-9抑郁量表分数为4.00 (1.00,8.00)分,高于对照组的1.00 (0.00,4.00)分,2组比较差异有统计学意义(P均<0.01);RE组GAD-7焦虑量表分数为2.00 (0.00,7.00)分,亦高于对照组的1.00 (0.00,3.00)分,比较差异也有统计学意义(P <0.01)。焦虑、抑郁与RE分级之间无明显相关性(P均>0.05)。RE患者症状的严重程度(r_s=0.481,P<0.01)、疾病对日常生活的影响与抑郁程度呈正相关(r_s=0.585,P<0.01),而与焦虑程度无关(r_s分别为0.090和0.038,P均>0.05)。结论焦虑和抑郁与RE的发病存在一定的相关性。RE患者的症状、疾病对日常生活的影响随着抑郁的加重而加重,而与焦虑程度无关。

Objective To explore the correlation between reflux esophagitis(RE)and anxiety and depression.Methods A total of361RE patients diagnosed by gastroscopy(RE group)and359healthy controls(control group)were enrolled in this study.All participants were evaluated with the PHQ?9depression scale,GAD?7anxiety scale and GerdQ.The anxiety and depression scores were statistically compared between two groups.The correlation between psychological factors,symptoms and daily life was analyzed according to theGerdQscore.Results ThescoreofPHQ?9depressionscaleintheREgroupwas4.00(1.00,8.00),significantly higher than1.00(0.00,4.00)in the control group(P<0.01).In the RE group,the score of GAD?7anxiety scale was2.00(0.00,7.00),significantly higher than1.00(0.00,3.00)in the control group(P<0.01).The scores of these two scales were not correlated with the severity of RE.The GerdQ score was utilized to classify the effect of RE symptoms upon the daily life as mild,moderate and severe.A positive correlation was observed between the depression score(rs=0.481,P<0.01),the severity of symptoms and the impact of disease on daily life(rs=0.585,P<0.01),whereas anxiety was not associated with the severity of these two factors(rs=0.090and rs=0.038,bothP>0.05).Conclusions Anxiety and depression are correlated with the in-cidence of RE to certain extent.The severity of symptoms and the impact of disease on daily life are aggravated with the deteriorated symptoms of depression,whereas anxiety is not correlated with these two factors.