ICU脓毒症患者血清降钙素原浓度与病原学类型的关系

Relation of serum procalcitonin concentration with pathogen type in ICU patients with sepsis

目的探讨ICU脓毒症患者血清降钙素原(PCT)浓度与病原学类型的关系。方法回顾性分析216例ICU脓毒症患者的临床资料,入院时检测PCT浓度,同时行体液或分泌物病原体培养,比较不同类型致病菌感染病例的PCT阳性率。结果 216例患者共行804份标本培养,符合致病菌标准共253份(31. 46%),其中革兰阴性致病菌、革兰阳性致病菌、真菌感染各192例、28例、33例。革兰阴性致病菌感染患者的PCT阳性率高于革兰阳性致病菌及真菌致病菌感染患者(均P <0. 05)。结论在ICU中,血清PCT阳性常见于革兰阴性致病菌感染病例,这对脓毒症患者的抗生素决策有一定的参考价值。

Objective To investigate the relation of serum procalcitonin(PCT)concentration with pathogen type in ICU patients with sepsis.Methods The clinical data of216septic patients in ICU were retrospectively analyzed.The PCT concentration was detected on admission,meanwhile,the pathogen culture of body fluids or secretions was conducted.The positive rate of PCT was compared among the cases infected by different pathogens.Results A total of804specimens from216patients were collected for culture,and pathogenic bacteria or fungi were found in253specimens(31.46%)including192specimens with Gram-negative pathogenic bacteria,28specimens with Gram-positive pathogenic bacteria and33specimen with fungal infection.The PCT positive rate of the patients infected by Gram-negative pathogenic bacteria was higher than that of the patients infected by Gram-positive pathogenic bacteria or fungi(all P<0.05).Conclusion Positive serum PCT is common in the cases infected by Gram-negative pathogenic bacteria in ICU,which provides a certain reference value for antibiotic decision-making in the patients with sepsis.