运动介导AMPK调控线粒体质量控制的机制研究进展

The Research Progress of Mechanisms of Exercise-Induced AMPK Regulating Mitochondrial Quality Control

作为高度动态化的细胞器,线粒体处于持续动态变化中,其生物发生、融合分裂和自噬之间的平衡对维持线粒体网络稳态至关重要。骨骼肌线粒体的运动性适应包括两个方面,即线粒体数量的增加及线粒体质量(结构与功能)的完善。运动不仅能够促进线粒体生物发生,同时亦可诱导、促进线粒体自噬等逆向适应,其中腺苷酸活化蛋白激酶(Amp activated protein kinase, AMPK)被认为在其中发挥关键作用。本研究综述了运动通过AMPK对线粒体质量控制产生的干预作用及具体分子机制。

Mitochondria are highly dynamic organelles that under continuous dynamic changes,and the balance between mitochondrial biogenesis,mitochondrial dynamics and mitophagy is crucial to maintain mitochondrial network.The mitochondrial adaption induced by exercise in skeletal muscle includes coordinated improvements in quantity(content)and quality(structure and function).Regular exercise training has known to promote mitochondrial biogenesis,but recent work has demonstrated that it also has a profound impact on mitochondrial dynamics(fusion and fission)and clearance(mitophagy),among which Amp activated protein kinase(AMPK)is considered to play an important role.In this paper,AMPK mediated effect and molecular mechanism of exercise on mitochondrial quality is reviewed.