c-abl与CDK2在新疆哈萨克族食管鳞癌早期发生中的作用

The Role of c-abl and CDK2 in Early Development of Xinjiang Kazak's Esophageal Cancer

目的:探讨细胞周期调控因子c-abl、CDK2在新疆哈萨克族食管鳞癌发生发展中的作用。方法:采用逆转录PCR方法在48例新疆哈萨克族食管鳞癌组织及远端无癌组织中检测c-abl、CDK2的表达。结果:在新疆哈萨克族食管鳞癌中:(1) c-abl和CDK2在癌组织与癌旁组织中的阳性表达率比较,差异均无统计学意义(P> 0. 05)。(2)在癌组织中CDK2表达与TNM分期有关(P=0. 040 <0. 05)。结论:CDK2表达与食管癌TNM分期有关,两基因直接或间接的通过细胞周期和凋亡在新疆哈萨克族食管鳞癌发生发展及侵袭过程中起作用。

Objective:To investigate the expression of c-abl and CDK2in esophageal squamous cell carcinoma(ESCC)and to analyze their clinicopathological significance.Methods:48ESCC specimens were taken from Xinjiang Kazaks patients and used in the study.Matched normal esophageal mucosal tissues were used as controls.The expression of c-abl and CDK2was detected by RT-PCR.Results:c-abl and CDK2expression in ESCC showed no significant difference with that in normal esophageal mucosal tissue(P>0.05).CDK2is correlated with differentiated TNM stages(P=0.040<0.05).Conclusion:High expression of c-abl and CDK2may be involved in the development and progression of ESCC.