埃索美拉唑联合阿莫西林、克拉霉素治疗胃溃疡幽门螺杆菌感染的疗效

Efficacy of esomeprazole combined with amoxicillin and clarithromycin in the treatment of gastric ulcer by Helicobacter pylori infection

目的 :研究埃索美拉唑联合阿莫西林、克拉霉素治疗胃溃疡幽门螺杆菌感染的临床价值。方法 :选取86例胃溃疡幽门螺杆菌感染患者,随机分为对照组和实验组各43例,对照组给予阿莫西林+克拉霉素+奥美拉唑治疗,实验组给予埃索美拉唑联合阿莫西林、克拉霉素治疗,观察两组患者治疗后的临床疗效。结果 :实验组治疗后的症状缓解时间、疼痛评分、溃疡面积、HP清除率、复发率、不良反应发生率及显效率等指标明显优于对照组(P <0.05)。结论:针对胃溃疡幽门螺杆菌感染患者实施埃索美拉唑联合阿莫西林、克拉霉素治疗的效果显著,安全可靠。

Objective:To study the clinical value of esomeprazole combined with amoxicillin and clarithromycin in the treatment of gastric ulcer by Helicobacter pylori infection.Methods:Eighty-six patients with gastric ulcer by Helicobacter pylori infection were selected and randomly divided into a control group and an experimental group with 43 patients each.The control group was treated with amoxicillin,clarithromycin and omeprazole while the experimental group with esomeprazole combined with amoxicillin and clarithromycin.The clinical efficacy of the two groups was compared after treatment.Results:The indications such as symptom relief time,pain score,ulcer area,Helicobacter pylori clearance rate and recurrence rate,incidence of adverse reactions and so on were much better in the experimental group than the control group after treatment(P<0.05).Conclusion:The therapy for the experimental group is significantly safe and reliable with exact efficacy.