经皮射频消融术与传统手术切除术治疗小肝癌的效果对比研究

Comparative study on the effects of percutaneous radiofrequency ablation and traditional surgical resection for small hepatocellular carcinoma

目的 :对比经皮射频消融术与传统手术切除术治疗小肝癌的效果。方法 :将采用经皮射频消融术处理的肝癌87例纳入消融组、传统手术处理的105例纳入手术组。对比近远期疗效指标。结果 :射频组与手术组的近期疗效、24个月存活率、无瘤存活率差异无统计学意义(P> 0.05)。射频组手术时间、卧床时间、住院时间、术后72 h ALT、AST、ALB变化率低于手术组,术后12个月AFP、术后24个月后的AFP与CEA高于手术组(P <0.05)。结论 :经皮射频消融术有明显的微创性,对肝功能损伤更轻,但术后的恶性肿瘤标志物水平更高。

Objective:To compare the effect of percutaneous radiofrequency ablation and traditional surgical resection in the treatment of small hepatocellular carcinoma.Methods:Eighty-seven cases of liver cancer treated with percutaneous radiofrequency ablation were selected as a radiofrequency group and 105 cases treated with traditional operation as an operation group.The short-and long-term curative effect indexes were compared.Results:There were no significant differences between the two groups in short-term curative effect,24 months survival rate and survival rate without tumor(P>0.05).The operation time,bed rest time,hospitalization time and the change rate in ALT,AST and ALB at postoperative 72 hours were lower and the AFP level at postoperative 12 months and the AFP and CEA levels at postoperative 24 months were higher in the radiofrequency group than the operation group(P<0.05).Conclusion:Percutaneous radiofrequency ablation has obviously minimally invasive effect and less injury to liver function,but the levels of postoperative malignant tumor markers are higher.