精子DNA碎片指数对囊胚发育的影响

Influence of sperm DNA fragmentation index on development of blastocyst

目的探讨分析体外受精-胚胎移植(IVF-ET)周期中男方精子DNA碎片指数(DFI)对囊胚发育的影响。方法选取本中心2017年1～12月收治的579例进行囊胚培养的IVF周期作为研究对象,按照男方DFI检测值分为低DFI组(DFI<20%,470例)和高DFI组(DFI≥20%,109例),比较两组的囊胚培养情况。结果低DFI组的囊胚形成率高于高DFI组,差异有统计学意义(P<0.05)。两组的可用囊胚率及优质囊胚率比较,差异无统计学意义(P>0.05)。结论 DFI低于20%时进行囊胚培养能获得更多的囊胚,但是在可用囊胚率及优质囊胚率上却不能带来明显的提高。

Objective To investigate the influence of sperm DNA fragmentation index(DFI)on development of blastocyst during in vitro fertilization-embryo transfer(IVE-ET)cycle.Methods A total of579IVF-ET cycles from January to December2017in our center were selected as the research object,and they were divided into the low DFI group(DFI<20%,470cases)and the high DFI group(DFI≥20%,109cases)based on the value of husband′s DFI,and the development of blastocyst of two groups was analyzed.Results The blastocyst formation rate of the low DFI group was higher than that of the high DFI group(P<0.05),and the useful blastocyst formation rate and high quality blastocyst formation rate of the two groups were similar,with no significant difference(P>0.05).Conclusion There will be a higher blastocyst formation rate when the DFI is below20%,however,the quality of blastocyst will not be improved.