基于功能连接的急性脑干梗死默认功能网络研究

Study of Default Mode Network Based on Functional Connections with Acute Brainstem Infarction

目的探讨急性期脑干梗死患者默认功能网络(Default Mode Network,DMN)的改变。方法对26例急性期脑干梗死患者(患者组)及26例志愿者(对照组)进行静息态MRI扫描,采用功能连接的方法以后扣带回(Posterior Cingulate Cortex,PCC)为种子点计算DMN,将患者组及对照组的DMN分布图进行双样本t检验比较两组之间的差异。结果患者组及对照组均获得DMN分布图,患者组与对照组比较,内侧前额叶与PCC之间的功能连接显著减低。结论急性期脑干梗死患者DMN内核心节点间功能连接的减低可能是其出现认知障碍的原因之一。

Objective To investigate the change of the default mode network(DMN)in acute brainstem infarction.Methods A total of26cases of acute brainstem infarction(patients group)and26volunteers(control group)underwent resting state fMRI scans,and functional connectivity was used to isolate DMN with posterior cingulate cortex(PCC)as the seed point.Two?sample t?test was performed to compare the difference of DMN maps between patients group and control group.Results DMN maps were obtained in the patients group and control group.The functional connection of patients group between the medial prefrontal cortex and PCC was significantly reduced compared with the control group.Conclusion The decrease of functional connectivity between core nodes in DMN in patients with acute brainstem infarction may be one of the causes of cognitive impairment.