新生儿缺血缺氧性脑病预后不良的危险因素Logistic回归分析

Logistic regression analysis of risk factors for poor prognosis of neonatal ischemic-hypoxic encephalopathy

目的分析新生儿缺血缺氧性脑病(HIE)预后不良的危险因素,为临床的治疗提供相关经验。方法回顾性分析我院125例HIE患儿的临床资料。根据患儿的预后情况将其分为预后不良组(35例)和预后良好组(90例)。分析HIE预后不良的危险因素。结果 125例HIE患儿预后不良发生率为28.00%。预后不良组中10 min Apgar评分<4分、伴有强直性惊厥、伴有脑干症状、开始接受正规治疗时间>48 h、重度HIE的患儿占比高于预后良好组(P<0.05)。10 min Apgar评分、伴有强直性惊厥、伴有脑干症状、开始接受正规治疗时间、HIE临床分度均是影响HIE患儿预后的独立危险因素(P<0.05)。结论影响HIE预后不良的危险因素较多,在制定HIE的临床治疗方案时应充分考虑以上因素。

Objective To analyze the risk factors of poor prognosis of neonatal hypoxic-ischemic encephalopathy(HIE),and to provide relevant experience for clinical treatment.Methods The clinical data of 125 children with HIE in our hospital were retrospectively analyzed.According to the prognosis of the children,they were divided into poor prognosis group(35 cases)and good prognosis group(90 cases).The risk factors of poor prognosis of HIE were analyzed.Results The incidence of poor prognosis in 125 children with HIE was 28.00%.In the poor prognosis group,the proportions of children with 10 min Apgar score<4,concurrent ankylosing convulsions,concurrent brainstem symptoms,time to start regular treatment>48 hours,severe HIE were higher than those of the good prognosis group(P<0.05).The 10 min Apgar score,concurrent ankylosing convulsion,concurrent brainstem symptoms,time to start regular treatment and clinical grading of HIE were all independent risk factors that affecting the prognosis of HIE children(P<0.05).Conclusion There are many risk factors affecting the poor prognosis of HIE.These factors should be fully taken into account when formulating the clinical treatment of HIE.