Betatrophin对非酒精性脂肪性肝病的预测价值

Value of betatrophin in predicting nonalcoholic fatty liver disease

目的探讨Betatrophin预测非酒精性脂肪性肝病(NAFLD)的价值。方法选取2017年1月-2018年1月在本院诊治的NAFLD患者160例作为研究对象,分为低脂肪含量组(LFC,n=65)和高脂肪含量组(HFC,n=95),另选取健康人群72例作为对照组。检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、TC、TG、HDL-C、LDL-C、ALT、AST、肌酐(Cr)、尿素氮(BUN)、尿酸(UA)和Betatrophin水平。计量资料多组间比较采用单因素方差分析,两两比较采用LSD-t检验,计数资料多组间比较采用χ2检验。血清Betatrophin与其他生化指标的相关性检验采用Pearson分析,采用多元线性逐步回归分析法分析影响脂肪含量的独立危险因素。结果LFC组和HFC组血清Betatrophin水平分别为(269. 3±15. 4) pg/ml、(290. 2±30. 5) pg/ml,明显高于对照组[(250. 2±20. 1)pg/ml,F=16. 134,P <0. 001],且HFC组高于LFC组(P <0. 05)。血清Betatrophin水平与脂肪含量、TC相关(r值分别0. 301、0. 128,P值分别为0. 012、0. 027)。多元线性逐步回归分析发现,脂肪含量与Betatrophin(t=3. 361,P=0. 005)、TG(t=2. 610,P=0. 010)和AST(t=2. 015,P=0. 012)呈正相关,而与HDL-C(t=-1. 847,P=0. 048)呈负相关。结论本研究发现血清Betatrophin水平越高,肝脂肪含量越高。血清Betatrophin或可作为NAFLD的预测指标,未来需要进一步深入研究。

Objective To investigate the value of betatrophin in predicting nonalcoholic fatty liver disease(NAFLD).Methods A total of 160 patients with NAFLD who were diagnosed and treated in our hospital from January 2017 to January 2018 were enrolled in this study and were divided into low fat content(LFC)group with 65 patients and high fat content(HFC)group with 95 patients.A total of 72 healthy individuals were enrolled as control group.Related indices were measured,including fasting plasma glucose(FPG),HbA1c,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Cr),blood urea nitrogen(BUN),uric acid(UA),and betatrophin.Comparison between multiple groups was made by one-way analysis of variance,and comparison between any two groups was made using the LSD-t test,comparison of categorical data between multiple groups was made by chi-square test.Pearson analysis was performed to investigate the correlation of serum betatrophin with other biochemical parameters,and multivariate linear stepwise regression analysis was used to analyze the independent risk factors for fat content.Results The LFC group and the HFC group had a significantly higher serum level of betatrophin than the control group(269.3±15.4 pg/ml and 290.2±30.5 pg/ml vs 250.2±20.1 pg/ml,F=16.134,P<0.001),and the HFC group had a higher level than the LFC group(P<0.05).The serum level of betatrophin was correlated with fat content and TC(r=0.301 and 0.128,P=0.012 and 0.027).The multiple linear stepwise regression analysis showed that fat content was positively correlated with betatrophin(t=3.361,P=0.005),TG(t=2.610,P=0.010),and AST(t=2.015,P=0.012)and was negatively correlated with HDL-C(t=-1.847,P=0.048).Conclusion Liver fat content increases with the increase in the serum level of betatrophin.Serum betatrophin may be used as a predictive factor for NAFLD,which needs further research in the future.