摘要
临床上经常会遇到结核合并抗-HCV阳性患者(TB-HCV),其中也包含了结核患者合并HCV现症感染者,这给临床管理和诊治带来了一定的困难。介绍了国内外TB-HCV流行率情况,并逐步分析了在TB-HCV患者诊治过程中可能发生的药物相互作用、药物性肝损伤、HCV再激活和TB再激活等系列问题。认为在诊疗TB-HCV患者时应该加强管理,选择恰当的治疗方案。
Tuberculosis patients with positive antibody to hepatitis C virus(TB-HCV patients)are often seen in clinical practice,and these TB-HCV patients include those with HCV infection.That makes the clinical management and diagnosis/treatment of TB-HCV difficult.This article introduces the prevalence of TB-HCV around the world,and analyzes the potential issues in the diagnosis and treatment of TB-HCV patients,such as drug-drug interactions,drug-induced liver injury,HCV reactivation,and TB reactivation.Through this review,it is recommended that the management should be strengthened and the appropriate therapeutic regimen should be selected in the diagnosis and treatment of TB-HCV patients.
作者
詹淑华
陈青
马世武
ZHAN Shuhua;CHEN Qing;MA Shiwu(Kunming General Hospital of Chengdu Military Command,Kunming Medical University,Kunming 650000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第12期2672-2676,共5页
Journal of Clinical Hepatology
基金
云南省中青年学术技术带头人项目(第十八批)
关键词
结核
肝炎病毒属
药物相互作用
药物性肝损伤
病毒激活
综述
tuberculosis
hepacivirus
drug-drug interactions
drug-induced liver injury
0x09virus activation
review
