益生菌联合序贯疗法治疗儿童幽门螺杆菌感染的疗效分析

Efficiency analysis of probiotics combined with sequential therapy in treating children with Helicobacter pylori infection

目的探讨双歧杆菌三联活菌散、布拉氏酵母菌散联合序贯疗法治疗儿童幽门螺杆菌感染的有效性及不良反应。方法选取幽门螺杆菌感染患儿125例,均给予序贯治疗10 d(奥美拉唑+阿莫西林克拉维酸钾治疗5 d,奥美拉唑+克拉霉素+甲硝唑治疗5 d),并随机分为A组45例(不加益生菌)、B组42例(联合双歧杆菌三联活菌散治疗)、C组38例(联合布拉氏酵母菌散治疗)。比较3组幽门螺杆菌的根治效果及药物的不良反应。结果治疗结束4周后,A、B、C组幽门螺杆菌根除率依次为64. 44%、88. 10%、84. 21%,B、C组的幽门螺杆菌根除率均显著高于A组(P <0. 05)。A、B、C组不良反应发生率依次为31. 11%、11. 90%、10. 53%,B、C组的不良反应发生率显著低于A组(P <0. 05)。结论双歧杆菌三联活菌散或布拉氏酵母菌散联合序贯疗法可以提高儿童幽门螺杆菌感染的根除率,并可降低药物的不良反应发生率。

Objective To investigate the efficacy and adverse reactions of bifidobacterium triple viable powder and saccharomyces boulardii sachets combined with sequential therapy in the treatment of children with helicobacter pylori(Hp)infection.Methods Totally 125 children with Hp infection were treated with sequential therapy for 10 days(omeprazole plus amoxicillin clavulanate for 5 days,omeprazole plus clarithromycin and metronidazole for 5 days),and then they were randomly divided into group A(n=45,without probiotics),group B(n=42,combined with bifidobacterium triple viable powder)and group C(n=38,combined with saccharomyces boulardii sachets).Eradication rate of Hp infecntion and adverse reactions were compared among three groups.Results Four weeks after treatment,the eradication rates of Hp infection in group A,B and C were 64.44%,88.10%and 84.21%respectively.The eradication rates of Hp infection in group B and C were significantly higher than group A(P<0.05).The incidence rates of adverse reactions in group A,B and C were 31.11%,11.90%and 10.53%respectively.The incidence rates of adverse reactions in group B and C were significantly lower than group A(P<0.05).Conclusion Bifidobacterium triple viable powder or saccharomyces boulardii sachets combined with sequential therapy can improve the eradication rate of Hp infection in children and reduce incidence rate of adverse reactions.