急性胆管炎患者谷丙转氨酶和谷草转氨酶的变化及意义

Change and significance of alanine aminotransferase and aspartate aminotransferase in patients with acute cholangitis

目的探讨急性胆管炎(AC)患者血清谷丙转氨酶(ALT)和谷草转氨酶(AST)的变化及意义。方法选取急性胆管炎患者112例作为AC组,另选取健康人群作为对照组。比较2组血清谷丙转氨酶(ALT)和谷草转氨酶(AST)的水平,以及不同严重程度AC患者血清ALT、AST的表达差异。结果 AC组患者血清中ALT和AST水平显著高于对照组(P <0. 05);轻度AC患者血清中AST和ALT表达水平低于中度AC患者,中度AC患者血清中AST和ALT表达水平低于重度AC患者。治疗后,AC组患者血清中AST和ALT表达较治疗前显著降低(P <0. 05)。AST和ALT联合检测诊断AC的灵敏度和特异度分别为97. 62%和97. 31%,显著高于单一指标检测诊断的灵敏度和特异度(P <0. 05)。结论急性胆管炎患者血清中AST和ALT表达明显升高,ALT和AST的联合检测可作为急性胆管炎的重要指标。

Objective To investigate the change and significance of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels in patients with acute cholangitis(AC).Methods A total of112AC patients were selected as AC group,and healthy people were selected as control group.The serum levels of ALT and AST were compared between two groups,and the levels of ALT and AST were compared between AC patients with different severity.Results The serum levels of ALT and AST in AC group were significantly higher than those in control group(P<0.05).The serum levels of AST and ALT in mild AC patients were lower than those in moderate AC patients,and the serum levels of AST and ALT in moderate AC patients were lower than those in severe AC patients.After treatment,the levels of serum AST and ALT in AC group were significantly lower than those before treatment(P<0.05).The sensitivity and specificity of AST combined with ALT detection in the diagnosis of AC were97.62%and97.31%respectively,which were significantly higher than those of single index detection(P<0.05).Conclusion The levels of serum AST and ALT in patients with AC increased significantly.The combined detection of ALT and AST can be used as an important indicator for acute cholangitis.