急性心肌梗死患者血小板相关参数的测定及意义

Determination and significance of Platelet related parameters in patients with acute myocardial infarction

目的评价AMI患者血小板相关参数的临床意义。方法选取来我院就诊的急性心梗患者(50例)和正常对照(100例),分析参与者的临床信息,检测并统计分析两组血小板计数(PLT)、平均体积(MPV)、体积分布宽度(PDW)及大血小板比率(P-LCR)等指标的差异,分析各指标在两组间的差异,分析各指标的临床意义。结果 AMI患者抽烟比例、血脂水平均高于正常对照组;AMI组MPV和P-LCR均显著高于对照组;而PLT和PDW在两组间无显著差异。ROC曲线分析发现MPV和P-LCR均具有成为AMI前期指标的潜能。结论血小板在AMI发生发展中发挥重要作用,MPV和P-LCR可作为AMI诊断的潜在指标。

Objective The aim of this study was to investigate the association of platelet related parameters in patients with acute myocardial infarction(AMI).Methods A total of 50 AMI patients,and 100 healthy controls(HCs)were consecutively enrolled in this study.Baseline data,such as age,gender,body mass index,diabetes mellitus,cigarette smoking,of participants were analyzed.Platelet parameters,including platelet count(PLT),mean platelet volume(MPV),platelet distribution width(PDW)and platelet-large cell ration(P-LCR)were measured.The receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of these parameters.Results The AMI patients had higher smoking rate and blood lipid level than the healthy controls.The MVP and P-LCR were higher in AMI patients;there were no difference of PLT and PDW between control and AMI patients.Moreover,the ROC curve showed that MPV and P-LCR could be sensitive for diagnosis of AMI.Conclusion Platelets are highly correlated with AMI pathogenesis,and MPV and P-LCR may serve as a sensitive biomarker for diagnosis of AMI.