促排助孕汤治疗肾虚肝郁型多囊卵巢综合征并发排卵异常性不孕症的临床疗效

Cupai Zhuyun Decoction in treatment of kidney deficiency and liver stagnation type of polycystic ovary syndrome and abnormal ovulation infertility: a clinical observation

目的研究促排助孕汤治疗肾虚肝郁型多囊卵巢综合征并发排卵异常性不孕症的临床疗效。方法选择2016年5月至2018年3月在我院接受诊治的92例肾虚肝郁型多囊卵巢综合征并发排卵异常性不孕症患者作为观察对象,依随机数字表法分对照组、研究组,各46例。对照组患者给予口服来曲唑治疗,研究组接受口服促排助孕汤治疗。对比2组患者治疗效果、周期排卵率、妊娠结局及治疗前后中医症候积分、性激素水平变化。结果研究组治疗总有效率80.4%高于对照组的58.7%(χ~2=5.134,P=0.024);周期排卵率74.6%高于对照组的45.7%(χ~2=24.184,P=0.001);月经复常率93.5%、妊娠率50.0%均高于对照组的78.3%、23.9%(χ~2=4.390,P=0.036;χ~2=6.718,P=0.014);2组治疗后中医症候积分促卵泡激素(FSH)、睾酮(T)、黄体生成素(LH)水平低于治疗前,研究组更低,差异有统计学意义(P<0.05)。结论促排助孕汤治疗肾虚肝郁型多囊卵巢综合征并发排卵异常性不孕症效果显著。

Objective To investigate the clinical effect of Cupai ahuyun Decoction in the treatment of kidney deficiency and liver stagnation type of polycystic ovary syndrome and abnormal ovulation infertility.Methods Ninety-two patients with kidney deficiency and liver stagnation type of polycystic ovary syndrome and abnormal ovulation infertility admitted to our hospital between May 2016 and March 2018 were included as the subjects in the study.All patients were randomly divided into the control group and study group(n=46 each).The control group was treated with oral letrozole,and the study group was treated with oral Cupaizhuyun Decoction.The treatment effect,periodic ovulation rate,pregnancy outcome,TCM symptom scores and sex hormone levels before and after treatment were compared between the two groups.Results The total effective rate in the study group was higher than that in the control group(80.4%vs.58.7%,χ2=5.134,P=0.024).The ovulation rate in the study group was higher than that in the control group(74.6%vs.45.7%,χ2=24.184,P=0.001).The menstrual recurrence rate and pregnancy rate in the study group were higher than those in the control group[93.5%vs.78.3%,50.0%vs.23.9%(χ2=4.390,P=0.036;χ2=6.718,P=0.014)].The scores of TCM syndromes and levels of serum FSH,T and LH in the two groups after the treatment were lower than those before the treatment,and the study group was lower than the control group(P<0.05).Conclusion The effect of Cupai Zhuyun Decoction in the treatment of kidney deficiency and liver stagnation type of polycystic ovary syndrome and abnormal ovulation infertility is significant.