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间质性肺疾病患者血清结缔组织生长因子表达及与涎液化糖链抗原-6水平的相关性 被引量:5

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摘要 间质性肺疾病作为一种弥漫性肺疾病,以间质纤维与肺泡炎症为特征,主要累及肺间质、细支气管与肺泡,具有较高发病率以及致死率,但该疾病早期无明显临床表现,若未及时诊断与治疗,可因呼吸衰竭而死亡,严重降低患者生存质量。结缔组织生长因子(connectivetissuegrowthfactor,CTGF)作为一种富含半胱氨酸分泌蛋白,在机体中发挥促进血管形成、细胞外基质合成以及细胞增殖、黏附与迁移作用[1]。涎液化糖链抗原-6(krebsvondenlungen-6,KL-6)是一种跨膜高相对分子质量黏蛋白,具有促进纤维细胞增殖、迁徙并影响纤维化发生发展进程的作用[2]。本研究对我院收治的126例间质性肺疾病患者进行血清CTGF、KL-6检测,探究CTGF与KL-6在该疾病中的临床意义,旨在为临床诊断与治疗提供理论依据。
作者 吴玉枝
出处 《中国药物与临床》 CAS 2018年第12期2182-2184,共3页 Chinese Remedies & Clinics
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