佐金平木、健脾化痰法与氟哌啶醇治疗小儿多发性抽动症对比研究

Clinical Effect of the Method of Assisting Metal, Calming Wood, Invigorating the Spleen, and Removing Phlegm Versus Haloperidol in Treatment of Tourette Syndrome

目的对比佐金平木、健脾化痰法与氟哌啶醇治疗小儿多发性抽动症的临床疗效。方法将140例多发性抽动症患儿随机分为治疗组和对照组各70例,对照组采用氟哌啶醇治疗,治疗组采用自拟佐金平木、健脾化痰法治疗,两组4周为1个疗程,3个疗程后判断疗效。比较两组行为评估、中医证候疗效。结果两组治疗后行为量表评分和社会能力部分均有改善(P<0.05或P<0.01),且治疗组较对照组改善更为明显(P<0.05)。治疗组中医证候疗效总有效率为88.6%,高于对照组的75.7%(P<0.05)。结论相对于氟哌啶醇,佐金平木、健脾化痰法能显著改善小儿多发性抽动症患儿的行为量表评分和社会能力部分,临床疗效显著,值得推广。

Objective To investigate the clinical effect of the method of assisting metal,calming wood,invigorating the spleen,and removing phlegm versus haloperidol in the treatment of Tourette syndrome.Methods A total of140children with Tourette syndrome were randomly divided into treatment group and control group,with70patients in each group.The children in the control group were treated with haloperidol,while those in the treatment group were treated with the method of assisting metal,calming wood,invigorating the spleen,and removing phlegm.Each course of treatment was4weeks,and clinical outcome was evaluated after3courses of treatment.Behavioral assessment and clinical outcome of TCM syndrome were compared between the two groups.Results After treatment,both groups had significant improvements in behavioral scale score and social competence(P<0.05or P<0.01),and the treatment group had significantly greater improvements than the control group(P<0.05).The treatment group had a significantly higher overall response rate than the control group(88.6%vs75.7%,P<0.05).Conclusion Compared with haloperidol,the method of assisting metal,calming wood,invigorating the spleen,and removing phlegm has a better clinical effect in the treatment of Tourette syndrome and can significantly improve children's behavioral scale score and social competence.Therefore,it holds promise for clinical application.