黄酮类中药单体治疗骨性关节炎作用的最新研究进展

Research Progress of Flavonoid Monomers in the Treatment of Osteoarthritis

骨性关节炎(OA)又称骨关节病、老年性关节炎、退行性关节炎,是老年人的常见疾病,属于中医"痹症"的范畴,与西医治疗相比;中医中药在治疗骨性关节炎方面具有丰富的理论和实践经验,其运用历史悠久,临床治疗方面效果较好且毒副作用较少;近些年来,在中药单体化合物治疗骨性关节炎的基础研究等方面,也有了较大的发展,尤其以黄酮类中药单体化合物为代表,因此本文就从其治疗骨性关节炎的基础研究文献方面上进行综述,主要包括对软骨细胞的增殖与凋亡、软骨细胞的代谢、对炎症细胞的代谢及对骨髓基质干细胞向软骨细胞分化等四个方面。

Osteoarthritis(OA),also known as osteoarthropathy,geriatric arthritis,and degenerative arthritis,is a common disease in the elderly.It belongs to Bi syndrome in TCM.It has been gained rich experience in OA treated with TCM therapy,which has a long history with better clinic effect and less toxic effect or side effect.In recent years,using TCM monomers,especially flavonoids,treating OA has made great progress.This study reviewed literatures about the research progresses of flavonoids in the treatment of osteoarthritis in terms of its effect on the proliferation and apoptosis of chondrocytes,metabolism of chondrocytes,the metabolism of inflammatory cells,and the differentiation of chondrocytes derived from human bone marrow stromal cells.