基于有限元法分析钙化软骨层的生物力学作用

Biomechanical function of calcified cartilage zone based on finite element analysis

背景:钙化软骨层为柔软的透明软骨与坚硬的软骨下骨能够稳定连接提供了重要保障。但目前对钙化软骨层在此中发挥的生物力学作用并不十分清楚。目的:利用有限元分析技术探讨钙化软骨层的生物力学作用。方法:自愿捐赠的人体正常股骨髁标本1个,依据仿生学原理,构建骨软骨复合组织的三维有限元模型。该模型包含透明软骨、钙化软骨层和软骨下骨3层结构。对模型分别施加压缩载荷(0.5-3.0 MPa)与剪切载荷(0.1-0.5 MPa),分析3层结构的应力分布情况。结果与结论:(1)在压缩与剪切载荷作用下,透明软骨的应力峰值范围分别为0.15-0.86 MPa与0.58-0.74 MPa,钙化软骨层的应力峰值范围分别为0.33-1.91 MPa与1.27-1.62 MPa,软骨下骨的应力峰值范围分别为0.55-3.22 MPa与2.36-2.98 MPa;(2)有限元分析法通过钙化软骨层的应力分布特征揭示了其生物力学作用,即介导负荷以逐级递增方式从透明软骨传至软骨下骨,使负荷在骨软骨复合组织的3层结构中得以顺利传递。

BACKGROUND:Calcified cartilage zone is important for the stable connection between soft hyaline cartilage and hard subchondral bone.But the biomechanical role of calcified cartilage zone played in this process is poorly understood.OBJECTIVE:To explore the biomechanical role of calcified cartilage zone using finite element analysis.METHODS:Human normal femoral condyle specimen from a volunteer was obtained.According to the principle of bionics,a three-dimensional finite element model of osteochondral tissue was created with three compositions:hyaline cartilage,calcified cartilage zone and subchondral bone.The compression load(0.5-3.0 MPa)and shear load(0.1-0.5 MPa)were applied to the model respectively in order to analyze the stress distributions of three compositions.RESULTS AND CONCLUSION:Under compression load and shear load,the maximum stress of hyaline cartilage was 0.15-0.86 MPa and 0.58-0.74 MPa,respectively.The maximum stress of calcified cartilage zone was 0.33-1.91 MPa and 1.27-1.62 MPa,respectively.The maximum stress of subchondral bone was 0.55-3.22 MPa and 2.36-2.98 MPa,respectively.Finite element analysis reveals the biomechanical role of calcified cartilage zone through the feature of its stress distribution.It mediates the load transfer from hyaline cartilage to subchondral bone in a stepwise-increase way,so that the load can transfer smoothly in three compositions of osteochondral tissue.