骨再生修复中的骨形态发生蛋白信号通路:精准调节与治疗靶点

Bone morphologic protein signaling pathway in bone regeneration and repair:accurate regulation and treatment targets

背景:骨的修复再生是治疗骨类疾病的难点,骨形态发生蛋白具有强大的调控骨量的功能,是调控骨稳态及骨再生的重要蛋白分子。目的:对骨形态发生蛋白信号通路在骨再生修复中的研究进展进行综述。方法:以"骨形态发生蛋白,Smad分子,组织工程,骨缺损,骨修复,骨类疾病,研究进展,bone morphogenetic protein,Smads,Tissue engineering,Bone defect,bone repair,bone disease,Progress in research"为关键词,检索CNKI、PubMed、Elsevier ScienceDirect、Web of Science等数据库1990至2018年发表的与骨形态发生蛋白信号通路及骨再生修复中相关的文献,将所有文章进行初筛后,对保留的文献进一步的归纳和总结分析。结果与讨论:骨形态发生蛋白分子在长骨、软骨、关节以及肌腱的生长发育中均发挥着重要的作用,骨形态发生蛋白2、7已投入临床上应用,用来治疗骨折不愈合、延迟愈合骨不连以及脊柱融合手术等,但骨形态发生蛋白对于骨再生修复中的强大的调控功能仍然值得进行更深一步的研究。骨形态发生蛋白及其相关分子在促进骨再生中取得了巨大进展,实现对骨形态发生蛋白信号的精准调节可能成为治疗骨类疾病的潜在治疗靶点。

BACKGROUND:Bone repair and regeneration is a difficulty in the treatment of bone diseases.Bone morphogenetic proteins can regulate bone mass and are critical for regulating bone homeostasis and bone regeneration.OBJECTIVE:To review the research progress of bone morphogenetic protein signal pathway in bone regeneration and repair.METHODS:Databases of CNKI,PubMed,Elsevier Science Direct,and Web of Science were retrieved with the keywords of“bone morphogenetic protein,Smads,tissue engineering,bone defect,bone repair,bone disease,progress in research”in English and Chinese,respectively from 1990 to 2018.Related literature on bone morphogenetic protein signaling pathways in bone regeneration was searched.After initial screening,eligible articles were further summarized and analyzed.RESULTS AND CONCLUSION:Bone morphogenetic protein molecules play an important role in the growth and development of long bone,cartilage,tendon and joints.Bone morphogenetic proteins 2 and 7 have been applied in the treatment of fracture nonunion,delayed union,and spine fusion,but bone morphogenetic protein regulation in the bone regeneration and repair still needs a further investigation.Roles of bone morphogenetic proteins and its related molecules in bone regeneration have made great progress.Precise regulation of bone morphogenetic protein signals may become a potential therapeutic target for bone diseases.