白细胞介素-18在器官移植作用中的研究进展

Research Progress of Interleukin-18 in Organ Transplantation

器官移植已成为治疗器官功能衰竭的有效手段,但术后的移植物排斥反应仍是临床面临的重要问题。白细胞介素-18(IL-18)属于IL-1家族成员,因其可以强效诱导产生干扰素-γ,因此最初被称为干扰素诱导因子。IL-18主要由单核/巨噬细胞产生,能增强T细胞以及自然杀伤细胞的生物学效应,而T细胞介导的免疫反应在器官移植后的排斥反应中起主导作用。已有研究表明IL-18在抗肿瘤、抗感染以及免疫调节方面均具有重要作用。最近又发现其在心脏、肝脏、肾脏、血管、骨髓移植后急性排斥反应中亦有重要调节作用。本文就IL-18在器官移植中的作用进行相关综述。

Organ transplantation was an effective method to treat organ failure,and postoperative graft rejection is still an important issue in the clinic.Interleukin-18(IL-18)is the members of the IL-1 family,because it can be powerful-induced interferon gamma,therefore,was originally called interferon inducing factor.IL-18 mainly produced by the monocyte/macrophage,it can enhance biological effect of T cells and natural killer cells.T cell-mediated immune response is play a leading role of rejection after organ transplantation.Il-18 plays an important role in anti-tumor,anti-infection and immune regulation.Recently,it has been found that it also plays an important role in the regulation of acute rejection after renal transplantation,liver transplantation,heart transplantation,vascular transplantation and bone marrow transplantation.The arm of this paper was to reviews the role of il-18 in organ transplantation.