非布司他治疗慢性肾脏病伴高尿酸血症的有效性与安全性

Efficacy and Safety of Febuxostat in the Treatment of Chronic Kidney Disease With Hyperuricemia

目的探究分析非布司他治疗慢性肾病伴高尿酸血症的有效性与安全性。方法选择83例慢性肾病伴高尿酸血症患者,采用数字随机分配的方法将其分为两组。对照组41例,接受常规治疗,实验组42例,在常规治疗的基础上加以实施非布司他治疗,对比两组患者临床治疗效果。结果实验组血肌酐、血尿素氮、血尿酸水平均低于对照组,P <0.05,组间比较差异具有统计学意义。两组均没有出现不良反应。结论在慢性肾病伴高尿酸血症治疗当中采取非布司他治疗能够有效控制患者病情,不良反应少,安全性和有效性高。

Objective To explore the efficacy and safety of febuxostat in the treatment of chronic kidney disease with hyperuricemia.Methods 83 patients with chronic kidney disease with hyperuricemia were selected and divided into two groups by digital random allocation.In the control group,41 cases were treated with routine treatment and 42 cases in the experimental group.On the basis of routine treatment,the treatment was performed by febuxostat therapy,and the effect of clinical treatment was compared between the two groups.Results The levels of serum creatinine,blood urea nitrogen and blood uric acid in the experimental group were significantly lower than those in the control group(P<0.05).There were no obvious adverse reactions in the two groups.Conclusion In the treatment of chronic kidney disease with hyperuricemia,febuxostat therapy can effectively control the patients’condition,with less adverse reactions and high safety and effectiveness.It is worth popularizing.