大剂量氨溴索治疗慢性阻塞性肺疾病的临床研究

Efficacy and Adverse Reactions of A Large Dose of Ambroxol in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨大剂量氨溴索治疗慢性阻塞性肺疾病急性加重期疗效及不良反应。方法选取2014年3月—2018年3月进入我科进行治疗的慢性阻塞性肺疾病急性加重期患者96例作为研究对象,将其随机分为对照组和观察组,每组各48例,对照组予以照常规剂量氨溴索治疗,观察组使用大剂量氨溴索治疗,对两组患者在经过一个疗程之后的病情发展情况。结果观察组的治疗效果优于对照组(P <0.05);观察组与对照组不良反应发生率差异无统计学意义(P> 0.05)。结论同常规剂量的氨溴索治疗效果相比较,大剂量的氨溴索表现出更加优异的临床治疗效果。两组患者在治疗的过程中均出现了不良反应,这说明在给患者使用氨溴索进行治疗时,医护人员应密切关注患者出现的不良反应情况,并及时采取措施对症处理。

Objective To investigate the efficacy and adverse reactions of a large dose of ambroxol in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods Ninety-six patients with acute exacerbation of chronic obstructive pulmonary disease who entered our hospital from March 2014 to March 2018 were selected as research subjects. They were randomly divided into control group and observation group, forty-eight patients in each group, the control group was treated with conventional doses of ambroxol, and the patients in the observation group were treated with high-dose ambroxol. The patient’s condition was observed and compared after one course of treatment.Results The therapeutic effect of the observation group was significantly better than that of the control group(P < 0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P > 0.05). Conclusion Compared with the conventional dose of ambroxol, high-dose ambroxol showed superior clinical results. Both groups of patients experienced adverse reactions during the treatment process. This tells when treating patients with ambroxol, the medical staff should pay close attention to the patient’s adverse reactions and take timely measures.