干细胞标记物Musashi-1与子宫内膜异位症关系的研究进展

Advances in Research on the Relationship between Cell Marker Musashi-1 and Endometriosis

子宫内膜异位症是雌激素依赖的多因素疾病。干细胞是机体内具有自我更新及多向分化潜能的未分化细胞群,能无限增埴分裂。EMs确切发病机制尚不完全清楚。近年国内外研究发现,子宫内膜干细胞的异常增殖、分化将导致EMs的发生,因此提出EMs可能是一种干细胞疾病。Musashi-1是最新发现的肿瘤干细胞标志物之一,其在Wnt/β-catenin等信号转导通路中发挥着重要作用,与EMs的发生、发展密切相关。现就干细胞标志物Musashi-1与子宫内膜异位症发病关系进行综述。

Endometriosis is a multifactorial disease of estrogen dependence,Stem cells are undifferentiated cells with self-renewal and multiple differentiation potentials within the body.It can multiply and divide indefinitely.The exact pathogenesis of EMs is not fully understood.In recent years,domestic and international studies have found that,abnormal proliferation and differentiation of endometrial stem cells will result in EMs,so it may be a stem cell disease.Musashi-1is one of the most recently discovered tumor stem cell markers,which plays an important role in the signal transduction pathway of Wnt/β-catenin,which is closely related to the occurrence and development of EMs.The relationship between stem cell marker Musashi-1and endometriosis is summarized as follows.