地衣芽胞杆菌联合幽门螺旋杆菌补救疗法的临床观察

Clinical Observation of Bacillus Licheniformis Combined with H.pylori Salvage Therapy

目的探讨地衣芽胞杆菌联合幽门螺旋杆菌补救治疗的临床疗效及不良反应。方法将胃镜及呼气试验确认的Hp感染者予标准三联疗法治疗清除2周,4周后复查Hp,采用随机数字表法将202例首次清除Hp失败者分为地衣芽胞杆菌联合补救疗法的观察组(n=102)和非联合疗法的对照组(n=100),对比分析根治率及不良反应率;结果观察组根治率优于对照组(89.13%vs 80.65%),但差异无统计学意义(P>0.05),不良反应发生率低于对照组(5.43%vs 19.35%),差异有统计学意义(P<0.05);结论地衣芽孢杆菌联合补救疗法清除HP不能加强根治效果,但可以减少药物引起的不良反应。

Objective To investigate the clinical efficacy and adverse reactions of Bacillus licheniformis combined with H.pylori,Hp.Methods Hp patients diagnosed by gastroscopy and breath test were treated with standard triple therapy for2weeks,and Hp,was rechecked4weeks later.202cases Hp losers were randomly divided into two groups:observation group(n=102)treated with Bacillus licheniformis combined with rescue therapy and control group(n=100)without combined therapy.The curative rate and adverse reaction rate were compared and analyzed.Results The radical cure rate of the observation group was better than that of the control group(89.13%vs80.65%),but the difference was not statistically significant(P>0.05),and the incidence of adverse reactions was lower than that of the control group(5.43%vs19.35%),the difference was statistically significant(P<0.05).Conclusion The removal of HP by Bacillus licheniformis combined with rescue therapy can not strengthen the curative effect,but can reduce the adverse reaction caused by drugs.