ⅢC~Ⅳ期上皮性卵巢癌预后影响因素分析

Analysis of Prognostic Factors for Stage ⅢC or Ⅳ Epithelial Ovarian Cancer

目的:探讨ⅢC～Ⅳ期上皮性卵巢癌患者预后的影响因素,为临床诊疗提供数据支持。方法:回顾分析广西医科大学附属肿瘤医院129例ⅢC～Ⅳ期上皮性卵巢癌患者的临床资料,包括年龄、临床分期、组织病理学类型与分级、手术残余病灶直径和术后化疗周期数等。分析评价各因素对ⅢC～Ⅳ期上皮性卵巢癌预后的影响。结果:单因素分析显示,年龄、手术残余病灶直径、术后化疗周期数与患者预后密切相关,临床分期、病理学类型与组织学分级对预后无显著影响。应用COX回归模型进行多因素分析,患者年龄≥50岁(RR=0.493,95%CI:0.308～0.790)、手术残余病灶直径≥1 cm(RR=2.527,95%CI:1.585～4.028)及术后化疗周期数<6次(RR=2.294,95%CI:1.464～3.593)为ⅢC～Ⅳ期上皮性卵巢癌患者预后的独立危险因素。结论:对于ⅢC～Ⅳ期上皮性卵巢癌患者,年龄越大、手术残余病灶直径越大、术后化疗周期数越少,预后越差。

Objective:To explore the prognostic factors of stageⅢC orⅣepithelial ovarian cancer and to provide data support for clinical diagnosis and treatment.Methods:Clinical date of patients with stageⅢC orⅣepithelial ovarian cancer in our hospital were analyzed retrospectively,including age,clinical stage,histopathological type and grade,size of postoperative residual disease and number of postoperative chemotherapy cycles.The effects of these factors on the prognosis of patients with stageⅢC orⅣepithelial ovarian cancer were evaluated.Results:Univariate analysis showed that age,size of postoperative residual disease and number of postoperative chemotherapy cycles were closely related to the prognosis of the patients.Clinical stage,histopathological type and grade were not statistically significant.Multivariate analysis using COX regression model showed that age≥50(RR=0.493,95%CI:0.308-0.790),size of postoperative residual disease≥1 cm(RR=2.527,95%CI:1.585-4.028)and number of postoperative chemotherapy cycles<6(RR=2.294,95%CI:1.464-3.593)were independent risk factors for prognosis in patients with stageⅢC orⅣepithelial ovarian cancer.Conclusions:For patients with stageⅢC orⅣepithelial ovarian cancer,they would have worse prognosis if the patient is the older or the size of postoperative residual disease is larger or the number of postoperative chemotherapy cycles is less.