GnRH-α对子宫内膜异位症腹腔镜术后患者的治疗效果分析

Treatment effect of GnRH-α on patients with endometriosis after laparoscopic surgery

目的探究子宫内膜异位症腹腔镜手术患者加用促性腺激素释放激素激动剂(GnRH-α)的治疗效果。方法选择2015年3月至2016年10月本院收治的子宫内膜异位症患者100例,随机分为两组各50例。两组均采用腹腔镜手术治疗,对照组术后加用米非司酮片治疗,观察组术后加用GnRH-α治疗,6个月后,比较两组临床疗效、Th1/Th2细胞因子、生殖激素水平、不良反应。结果观察组总有效率、IL-2、IFN-γ水平、IL-2/IL-10、IFN-γ/IL-4均较对照组高,IL-10、IL-4水平、E2、LH、FSH水平、疾病复发率均较对照组低,差异有统计学意义(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论 GnRH-α联合腹腔镜手术可提高子宫内膜异位症临床疗效,恢复Th1/Th2细胞平衡,降低生殖激素水平及疾病复发率,安全性较高。

Objective To investigate the effect of gonadotropin-releasing hormone angonist(GnRH-α)on reproductive hormone and Th1/Th2cell balance in endometriosis patients with laparoscopic surgery.Methods A total of100patients with endometriosis in the hospital from March2015to October2016were randomly divided into two groups,with50cases in each group.Two groups were given laparoscopic surgery.After surgery,control group was given mifepristone tablets,while observation group was treated with GnRH-α.After6months,the clinical efficacy,level of Th1/Th2cytokines,reproductive hormone level,adverse reactions were compared between the two groups.Results The total effective rate,IL-29IFN-γ,IL-2/IL-10,IFN-γ/IL-4in observation group were higher than those in control group,while the IL-10,IL-4,E2,LH,FSH,recurrence rate in observation group were lower than control group(P<0.05);There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion GnRH-αcombined with laparoscopic surgery in treatment of endometriosis can increase clinical efficacy,recover Thl/Th2cell balance,decrease reproductive hormone levels and recurrence rate,which has higher safety.