2XU D Q,MATTNER P G,PRASAD K,et al. An expeditious synthesis of a biscyclam with an aromatic linker[ J]. Tetrahed- ron Lett,1996,37(30) :5301 -5304.
3MICHAL A,LOLIIS S H. Direct synthesis of 1,1'-[ 1,4-phenylenebis ( methylene ) ] -bis-1,4, 8, 11 -tetraazacyclotetradecane octahydroehloride(AMD 3100) without the use of protecting groups [ J ]. J Org Chem,2003,68 ( 16 ) :6435 - 6436.
4YANG W,CHRISTEN M G,MICHAEL S,et al. Facile N-1 protection of cyelam, cyclen and 1,4, 7-triazacyclononane [ J]. Tetrahedron Lett,2003,44(12) :2481 -2483.
5GINA C V, GRAEME M, ELIZABETH A. ct al. Configurationally restricted bismacrocyclic CXCR4 receptor antagonists [J]. J Med Chem,2006,49(21 ) :6162 -6165.
6BRIDGER G J, SKERI.J R T, VREESE K D, et al. Synthesis and structure-activity relationships of phenylenebis (methylene) linked bis tetraazamaerocyclcs that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker[ J]. J Med Chem, 1995,38 (2) :366 -378.
7De CLERCQ E. The bicyclam AMD3100 story[J]. Nat Rev Drug Discov ,2003,2 (7) :581 - 587.
8CIAMPOLINI M, FABBRIZZI L, PEROTTI A, et al. Dinickel and dicopper complexes with N,N-linked bis (cyclam) ligands. An ideal system for the investiga- tion of electrostatic effects on the redox behavior of pairs of metal ions [ J ]. Inorg Chem, 1987,26 ( 21 ) : 3527 - 3533.
9BRIDGER G J,SKERLJ R T,THORNTON D,et al. Synthesis and structure-activity relationships of phen- ylenebis ( methylene ) -linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker[ J]. J Med Chem,1995,38(2) :366 -378.
10YANG W, GIANDOMENICO C M, SARTORI M, et al. Facile N-1 protection of cyclam, cyclen and 1,4,7- triazacyclononane [ J ]. Tetrahedron Lett, 2003, 44 (12) :2481 - 2483.
