初治肺结核患者的生活质量现况调查

Health-related Quality of Life in Patients with Tuberculosis Who Completed Treatment

目的调查初次完成短程督导化疗(directly observed treatment short-course,DOTS)2年后的肺结核患者的健康相关生活质量水平及其与健康人群对比情况。方法本研究为病例对照研究。2017年7-9月,采用方便抽样法选取上海市某三级甲等专科医院完成DOTS的206例肺结核患者为病例组,同时段选取该院所在社区的健康居民为对照组,采用健康调查简表调查分析其生活质量现况。结果肺结核组的生理健康相关生活质量及精神健康相关生活质量得分均高于对照组(P<0.05);多元线性回归分析结果显示,年龄、持续症状是肺结核患者生理健康相关生活质量的影响因素(P<0.001);开始治疗前的痰涂片结果是肺结核患者精神健康相关生活质量的影响因素(P<0.05)。结论 DOTS治疗的有效性得到肯定,建议临床工作者可采用有效举措减少DOTS治疗后的持续症状,以提高肺结核患者的健康相关生活质量。

Objective To investigate the level of health-related quality of life(HRQoL)among patients with pulmonary tuberculosis(TB)within 2 years after completion of the directly observed treatment short course(DOTS),and to compare their HRQoL with a comparison group of the normal community population.Methods A case-control study was conducted.Totally 206 pulmonary TB patients who had completed DOTS from July to September 2017 were selected as the observation group,and the individuals without TB were selected as the control group.HRQoL was measured by using the Short Form 36 Health Survey(SF-36).Results The scores of physical HRQoL and mental HRQoL in pulmonary TB group were higher than those in control group(P<0.05).Multiple linear regression showed that older age and presence of persistent symptoms after completion of DOTS were related to the physical HRQoL in TB patients(P<0.001).The result of sputum smear before treatment was the influencing factors of mental HRQoL in TB patients(P<0.05).Conclusions The effectiveness of DOTS treatment has been affirmed.It is suggested that clinicians should take effective measures to reduce the persistent symptoms after DOTS treatment,and to improve the HRQoL of pulmonary TB patients.