中医外治法治疗恶性肿瘤胸腔积液的疗效及安全性系统评价

Systematic review of efficacy and safety of external therapy of Chinese medicine for malignant pleural effusion

[目的]系统评价中药外治法治疗恶性胸腔积液有效性及安全性。[方法]计算机检索中文及外文据库从建库至2017年10月发表中医外治法治疗恶性胸腔积液的随机对照研究(RCT)文献,对纳入文献质量进行分析后,采用Revman 5.3软件进行Meta分析。[结果]纳入13个RCT,研究病例共724例。Meta分析结果示:单独使用中医外治法或常规治疗联合中医外治法不仅有效控制恶性胸腔积液,亦可改善患者临床症状,提高生活质量;不良反应主要为皮肤过敏,无明显骨髓抑制及肝肾毒性。[结论]中医外治疗法治疗恶性胸腔积液有较好疗效及安全性,同时上述结果可靠性及稳定性需要更大样本及高质量RCT加以证实。

[Objective]To evaluate the efficacy and safety of external therapy of Chinese medicine in the treatment of malignant pleural effusion(MPE).[Methods]Randomized controlled study(Meta)of Chinese medicine and foreign language database was used to retrieve the randomized controlled trials(RCT)of external therapy of Chinese medicine for the treatment of MPE from database to October2017.The quality of the included literatures was analyzed and Revman analysis was performed.[Results]Thinteen trials involved724patients were included.Meta analysis results show that the single use external medicine or combined with routine treatment method not only can effectively control the MPE,but improve clinical symptoms,and improve the life and quantity of the patients;adverse reaction include skin allergy,bone marrow suppression and the liver and kidney toxicity are not obvious.[Conclusion]The external treatment of traditional Chinese medicine has good efficacy and safety in the treatment of MPE,and the reliability and stability of the above results need to be confirmed by a larger sample and high-quality RCT.