健康体检成年人群幽门螺杆菌感染的相关因素研究

Study on related factors of Helicobacter pylori infection in adults with physical examination

目的探讨本市区域健康体检成年人群幽门螺杆菌(Helicobacter pylori,Hp)感染情况及Hp感染的相关影响因素,为幽门螺杆菌感染的预防和治疗提供一定的依据。方法随机抽取2015年3月～2018年3月期间在我院实行14C尿素试验测定Hp感染的4150例健康体检的成年人作为临床观察对象。采用随机数字表法分成未感染组(Hp感染结果为阴性,2282例)和感染组(Hp感染结果为阳性,1868例)。对比观察两组健康体检成年人群的性别、年龄、胃病诊疗史、喝酒史、抽烟史、是否生吃果蔬前削皮以及是否喜食干硬食物对Hp感染的影响。结果男性感染率53.54%高于女性感染率46.34%;中年(41～60岁)人群感染的概率高于青年(18～40岁)人群感染率及老年(61～85岁)人群感染率;有胃病诊疗史的感染率高于无胃病诊疗史的感染率;有喝酒史的感染率较无喝酒史的感染率明显高;有抽烟史的感染率较无抽烟史的感染率明显要高;生吃果蔬前削皮的感染率比生吃果蔬前不削皮的感染率要低;喜食干硬食物的人群感染率较不喜食干硬食物的感染率要高,比较差异均有统计学意义(P<0.05)。结论健康体检成年人群幽门螺杆菌(Hp)感染与人群的性别、年龄、胃病诊疗史、喝酒史、抽烟史、是否生吃果蔬前削皮以及是否喜食干硬食物因素息息相关,具有较高的临床价值。

Objective To investigate the infection status of Helicobacter pylori(Hp)and the related factors of Hp infection in adults with physical examination of the city,and to provide a basis for the prevention and treatment of Helicobacter pylori infection.Methods A total of4150adults with physical examination who underwent14C urea test in our hospital from March2015to March2018were randomly selected as clinical observation subjects.The patients were divided into the uninfected group(Hp infection was negative,2282cases)and the infection group(Hp infection was positive,1868cases)using the random number table method.The gender,age,history of gastroenterology,history of drinking,history of smoking,whether to peel before eating raw fruits and vegetables,and whether to like eating hard dry foods on HP infection were compared.Results The probability of male infection was53.54%,higher than the probability of female infection(46.34%).The probability of infection in middle-aged(41-60years old)population was higher than that of young people(18-40years old)and elderly population(61-85years old).The probability of infection with a history of gastroenterology was higher than that of a history without gastroenterology.The probability of infection with a history of drinking was obviously higher than without a history of drinking.The incidence of infection with a history of smoking was significantly higher than the probability of infection without smoking history.The infection rate of peeling before eating raw fruits and vegetables was lower than that of not peeling before eating raw fruits and vegetables.The infection rate of people who like dry and hard food was higher than that of people who don’t like dry and hard food,and the difference was statistically significant(P<0.05).Conclusion Helicobacter pylori(Hp)infection in healthy adult population is closely related to gender,age,history of gastroenterology,history of drinking,history of smoking,whether to peel before eating